K
Kevin E. Thorpe
Researcher at University of Toronto
Publications - 230
Citations - 19390
Kevin E. Thorpe is an academic researcher from University of Toronto. The author has contributed to research in topics: Randomized controlled trial & Medicine. The author has an hindex of 51, co-authored 202 publications receiving 15861 citations. Previous affiliations of Kevin E. Thorpe include St. Michael's Hospital & St. Michael's GAA, Sligo.
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Journal ArticleDOI
Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators.
H.J.M. Barnett,D W Taylor,Michael Eliasziw,Allan J. Fox,Gary G. Ferguson,Richard Haynes,R N Rankin,G. P. Clagett,Vladimir Hachinski,David L. Sackett,Kevin E. Thorpe,Heather Meldrum,J. D. Spence +12 more
TL;DR: Benefit of carotid endarterectomy was greatest among men, patients with recent stroke as the qualifying event, and patients with hemispheric symptoms, and decisions about treatment for patients in this category must take into account recognized risk factors.
Journal ArticleDOI
A pragmatic–explanatory continuum indicator summary (PRECIS): a tool to help trial designers
Kevin E. Thorpe,Merrick Zwarenstein,Andrew D Oxman,Shaun Treweek,Curt D. Furberg,Douglas G. Altman,Sean Tunis,Eduardo Bergel,Ian Harvey,David J. Magid,Kalipso Chalkidou +10 more
TL;DR: A tool to assist trialists in making design decisions that are consistent with their trial's stated purpose is proposed, with 10 key domains and which identifies criteria to help researchers determine how pragmatic or explanatory their trial is.
Journal ArticleDOI
The PRECIS-2 tool: designing trials that are fit for purpose
Kirsty Loudon,Shaun Treweek,Frank Sullivan,Peter T. Donnan,Kevin E. Thorpe,Merrick Zwarenstein +5 more
TL;DR: Advice is given on how to use an improved, validated version of PRECIS, which has been developed with the help of over 80 international trialists, clinicians, and policymakers, to support the explicit matching of design decisions to how the trial results are intended to be used.
Journal ArticleDOI
Atrial Fibrillation in Patients with Cryptogenic Stroke
David J. Gladstone,Melanie Spring,Paul Dorian,Val Panzov,Kevin E. Thorpe,Haris M. Vaid,Andreas Laupacis,Robert Côté,Mukul Sharma,John A. Blakely,Ashfaq Shuaib,Vladimir Hachinski,Shelagh B. Coutts,Demetrios J. Sahlas,Phil Teal,Samuel Yip,J. David Spence,Brian Buck,Steve Verreault,Leanne K. Casaubon,Andrew M Penn,Daniel Selchen,Albert Y. Jin,David Howse,Manu Mehdiratta,Karl Boyle,Richard I. Aviv,Moira K. Kapral,Muhammad Mamdani +28 more
TL;DR: Noninvasive ambulatory ECG monitoring for a target of 30 days significantly improved the detection of atrial fibrillation by a factor of more than five and nearly doubled the rate of anticoagulant treatment, as compared with the standard practice of short-duration ECG Monitoring.
Journal ArticleDOI
Relative Contribution of Residual Renal Function and Peritoneal Clearance to Adequacy of Dialysis: A Reanalysis of the CANUSA Study
TL;DR: The assumption of equivalence of peritoneal and renal clearances is not supported by these data, and recommendations for adequateperitoneal dialysis need to be reevaluated in light of these observations.