K
Kevin J. Mitchell
Researcher at Trinity College, Dublin
Publications - 93
Citations - 6665
Kevin J. Mitchell is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Semaphorin & Plexin. The author has an hindex of 34, co-authored 91 publications receiving 6113 citations. Previous affiliations of Kevin J. Mitchell include University of California & University of Glasgow.
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Journal ArticleDOI
Roundabout Controls Axon Crossing of the CNS Midline and Defines a Novel Subfamily of Evolutionarily Conserved Guidance Receptors
Thomas Kidd,Katja Brose,Kevin J. Mitchell,Richard D. Fetter,Marc Tessier-Lavigne,Corey S. Goodman,Guy Tear,Guy Tear +7 more
TL;DR: It is shown that robo encodes an axon guidance receptor that defines a novel subfamily of immunoglobulin superfamily proteins that is highly conserved from fruit flies to mammals.
Journal ArticleDOI
frazzled Encodes a Drosophila Member of the DCC Immunoglobulin Subfamily and Is Required for CNS and Motor Axon Guidance
Peter A. Kolodziej,Peter A. Kolodziej,Leslie C. Timpe,Kevin J. Mitchell,Sharon R. Fried,Corey S. Goodman,Lily Yeh Jan,Yuh Nung Jan +7 more
TL;DR: The identified Drosophila frazzled gene and vertebrate studies showing binding of DCC to netrin suggest that Frazzled may function in vivo as a receptor or component of a receptor mediating Netrin-dependent axon guidance.
Journal ArticleDOI
Genetic Analysis of Netrin Genes in Drosophila: Netrins Guide CNS Commissural Axons and Peripheral Motor Axons
Kevin J. Mitchell,Jennifer L Doyle,Tito Serafini,Timothy E. Kennedy,Marc Tessier-Lavigne,Corey S. Goodman,Barry J. Dickson +6 more
TL;DR: Two tandem Netrin genes in Drosophila are expressed at the midline of the developing CNS and in different subsets of neurons, muscles, and epidermal patches, indicating that the pattern of Netrin expression is crucial and that Netrins function as instructive cues.
Journal ArticleDOI
Functional analysis of secreted and transmembrane proteins critical to mouse development.
Kevin J. Mitchell,Kathy I. Pinson,Olivia G. Kelly,Jane Brennan,Joel Zupicich,Paul Scherz,Philip A. Leighton,Lisa V. Goodrich,Xiaowei Lu,Brian Avery,Peri Tate,Kariena K. Dill,Edivinia Pangilinan,Paul Wakenight,Marc Tessier-Lavigne,William C. Skarnes +15 more
TL;DR: The successful application of a modified gene-trap approach, the secretory trap, to systematically analyze the functions in vivo of large numbers of genes encoding secreted and membrane proteins is described.
Journal ArticleDOI
Defining brain wiring patterns and mechanisms through gene trapping in mice
Philip A. Leighton,Kevin J. Mitchell,Kevin J. Mitchell,Lisa V. Goodrich,Xiaowei Lu,Kathy I. Pinson,Paul Scherz,William C. Skarnes,Marc Tessier-Lavigne +8 more
TL;DR: A phenotype-based gene-trap screen in mice designed for the large-scale identification of genes controlling the formation of the trillions of connections in the mammalian brain is described.