K
Kevin Staras
Researcher at University of Sussex
Publications - 68
Citations - 3565
Kevin Staras is an academic researcher from University of Sussex. The author has contributed to research in topics: Synaptic vesicle & Vesicle. The author has an hindex of 32, co-authored 65 publications receiving 3277 citations. Previous affiliations of Kevin Staras include University of California, Berkeley & University College London.
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Journal ArticleDOI
The probability of neurotransmitter release: variability and feedback control at single synapses.
Tiago Branco,Kevin Staras +1 more
TL;DR: This work has demonstrated that synaptic terminals can individually set their neurotransmitter release probability dynamically through local feedback regulation, and this local tuning of transmission has important implications for current models of single-neuron computation.
Journal ArticleDOI
Local Dendritic Activity Sets Release Probability at Hippocampal Synapses
TL;DR: In this paper, the authors measured pr at single presynaptic terminals in connected pairs of hippocampal neurons and found that local dendritic activity is the major determinant of basal release probability.
Journal ArticleDOI
Constitutive sharing of recycling synaptic vesicles between presynaptic boutons
TL;DR: The results demonstrate that synaptic vesicle recycling is not confined to individual presynaptic terminals as is widely believed; rather, a substantial proportion of recycling vesicles are shared constitutively between boutons.
Local dendritic activity sets release probability at hippocampal synapses
TL;DR: The results indicate that local dendritic activity is the major determinant of basal release probability, and it is suggested that this feedback regulation might be required to maintain synapses in their operational range.
Journal ArticleDOI
XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia
Nicolas C. Hoch,Hana Hanzlikova,Stuart L. Rulten,Martine Tétreault,Emilia Komulainen,Limei Ju,Peter Hornyak,Zhihong Zeng,William Gittens,Stephanie Rey,Kevin Staras,Grazia M.S. Mancini,Peter J. McKinnon,Zhao-Qi Wang,Justin D. Wagner,Grace Yoon,Keith W. Caldecott +16 more
TL;DR: It is shown that biallelic mutations in the human XRCC1 gene are associated with ocular motor apraxia, axonal neuropathy, and progressive cerebellar ataxia, and genetic deletion of Parp1 rescued normal Cerebellar ADP-ribose levels and reduced the loss of cerebellary neurons and ataxic mice in Xrcc1-defective mice.