P
Peter J. McKinnon
Researcher at St. Jude Children's Research Hospital
Publications - 122
Citations - 12718
Peter J. McKinnon is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: DNA repair & DNA damage. The author has an hindex of 55, co-authored 117 publications receiving 11630 citations. Previous affiliations of Peter J. McKinnon include American Association For Cancer Research & University of Sydney.
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Journal ArticleDOI
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
John R. Jeffers,Evan Parganas,Evan Parganas,Youngsoo Lee,Chunying Yang,Jinling Wang,Jennifer Brennan,Kirsteen H. Maclean,Jia-wen Han,Thomas Chittenden,James N. Ihle,James N. Ihle,Peter J. McKinnon,John L. Cleveland,Gerard P. Zambetti +14 more
TL;DR: It is reported that Puma is essential for hematopoietic cell death triggered by ionizing radiation, deregulated c-Myc expression, and cytokine withdrawal, and required for IR-induced death throughout the developing nervous system and accounts for nearly all of the apoptotic activity attributed to p53 under these conditions.
Journal ArticleDOI
Subtypes of medulloblastoma have distinct developmental origins
Paul Gibson,Yiai Tong,Giles W. Robinson,Margaret C. Thompson,D. Spencer Currle,Christopher G Eden,Tanya A. Kranenburg,Twala L. Hogg,Helen Poppleton,Julie Martin,David B. Finkelstein,Stanley Pounds,Aaron Weiss,Zoltan Patay,Matthew A. Scoggins,Robert J. Ogg,Yanxin Pei,Zeng-Jie Yang,Sonja N. Brun,Youngsoo Lee,Frederique Zindy,Janet C. Lindsey,Makoto Mark Taketo,Frederick A. Boop,Robert A. Sanford,Amar Gajjar,Steven C. Clifford,Martine F. Roussel,Peter J. McKinnon,David H. Gutmann,David W. Ellison,Robert J. Wechsler-Reya,Richard J. Gilbertson +32 more
TL;DR: Evidence is provided that a discrete subtype of medulloblastoma that contains activating mutations in the WNT pathway effector CTNNB1 (hereafter, WNT subtype) arises outside the cerebellum from cells of the dorsal brainstem, the first evidence, to the authors' knowledge, that subtypes of medULLoblastomas have distinct cellular origins.
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Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development
Oleg Lagutin,Changqi C. Zhu,Daisuke Kobayashi,Jacek Topczewski,Kenji Shimamura,Luis Puelles,Helen R. Russell,Peter J. McKinnon,Lilianna Solnica-Krezel,Guillermo Oliver +9 more
TL;DR: It is demonstrated that regionalization of the vertebrate forebrain involves repression of Wnt1 expression by Six3 within the anterior neuroectoderm, and this results support the hypothesis that a Wnt signal gradient specifies posterior fates in the anterior neural plate.
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Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.
TL;DR: It is suggested that many of the abnormal stress responses seen in cells lacking ATM, NBS1, or BRCA1 result from a failure of ATM migration to sites of DNA breaks and a resultant lack of SMC1 phosphorylation.
Journal ArticleDOI
Requirement for Atm in Ionizing Radiation-Induced Cell Death in the Developing Central Nervous System
TL;DR: In wild-type, but not Atm-/- mice, up-regulation of p53 coincided with cell death, suggesting that Atn-dependent apoptosis in the CNS is mediated by p53, and p53 null mice showed a similar lack of radiation-induced cell death in the developing nervous system.