K
Kevin Y. Zhang
Researcher at Johns Hopkins University
Publications - 8
Citations - 61
Kevin Y. Zhang is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Transplantation & Retinal ganglion cell. The author has an hindex of 2, co-authored 4 publications receiving 7 citations. Previous affiliations of Kevin Y. Zhang include Johns Hopkins University School of Medicine.
Papers
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Journal ArticleDOI
Role of the Internal Limiting Membrane in Structural Engraftment and Topographic Spacing of Transplanted Human Stem Cell-Derived Retinal Ganglion Cells.
Kevin Y. Zhang,Caitlyn Tuffy,Joseph L. Mertz,Sarah Quillen,Laurence Wechsler,Harry A. Quigley,Donald J. Zack,Thomas V. Johnson +7 more
TL;DR: In this article, the cellular permeability of the internal limiting membrane (ILM) was increased for retinal ganglion cell (RGC) transplantation, and extracellular matrix digestion using proteolytic enzymes achieved ILM disruption while minimizing retinal toxicity and preserving glial reactivity.
Journal ArticleDOI
Retinal Ganglion Cell Transplantation: Approaches for Overcoming Challenges to Functional Integration
TL;DR: The current state of experimental RGC transplantation is summarized in this paper, and a set of standard approaches to quantifying and reporting experimental outcomes is proposed to guide a collective effort toward functional RGC replacement and optic nerve regeneration.
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The internal limiting membrane: Roles in retinal development and implications for emerging ocular therapies.
Kevin Y. Zhang,Thomas V. Johnson +1 more
TL;DR: This article examined how retinal neurons, glia, and vasculature interact with individual extracellular matrix constituents at the internal limiting membrane (ILM) and discussed approaches for achieving retinal parenchymal targeting of gene vectors and cell transplants delivered into the vitreous cavity.
Journal ArticleDOI
Analyses of transplanted human retinal ganglion cell morphology and localization in murine organotypic retinal explant culture
Kevin Y. Zhang,Thomas V. Johnson +1 more
TL;DR: Zhang et al. as mentioned in this paper presented a protocol for ex vivo human RGC transplantation on flatmounted murine organotypic retinal explants, providing a robust platform for studying donor RGC survival, dendritic stratification, topographic distribution, donor-host interactions, and pro-engraftment strategies.
Journal ArticleDOI
Loss of Retinogeniculate Synaptic Function in the DBA/2J Mouse Model of Glaucoma
Jennie C. Smith,Kevin Y. Zhang,Asia L Sladek,Jennifer Thompson,Elizabeth R. Bierlein,Ashish Bhandari,Matthew J. Van Hook +6 more
TL;DR: These findings identify glaucoma- and IOP-associated functional deficits in an important subcortical RGC projection target and sheds light on the processes linking IOP to vision loss and will be critical for informing future diagnostic approaches and vision-restoration therapies.