K
Khalid Al-Nedawi
Researcher at McMaster University
Publications - 27
Citations - 4039
Khalid Al-Nedawi is an academic researcher from McMaster University. The author has contributed to research in topics: Microvesicles & Cancer cell. The author has an hindex of 16, co-authored 26 publications receiving 3604 citations. Previous affiliations of Khalid Al-Nedawi include Polish Academy of Sciences & McMaster-Carr.
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Journal ArticleDOI
Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
Khalid Al-Nedawi,Brian Meehan,Johann Micallef,Vladimir Lhotak,Linda May,Abhijit Guha,Janusz Rak +6 more
TL;DR: It is shown that EGFRvIII can be 'shared' between glioma cells by intercellular transfer of membrane-derived microvesicles ('oncosomes'), which can contribute to a horizontal propagation of oncogenes and their associated transforming phenotype among subsets of cancer cells.
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Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR
TL;DR: It is proposed that oncogene-containing tumor cell-derived MVs could act as a unique form of angiogenesis-modulating stimuli and are capable of switching endothelial cells to act in an autocrine mode.
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Microvesicles as mediators of intercellular communication in cancer—the emerging science of cellular ‘debris’
TL;DR: The molecular mechanisms and mediators of MV-based intercellular communication (cancer vesiculome) are explored with the hope of using this information as a possible source of therapeutic targets and disease biomarkers in cancer.
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Microvesicles: messengers and mediators of tumor progression.
TL;DR: Microvesicles can be retrieved from the circulating blood of cancer patients, and reveal the presence of oncogenes in their tumors, thereby potentially serving as information-rich prognostic and predictive biomarkers.
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Gut commensal microvesicles reproduce parent bacterial signals to host immune and enteric nervous systems
Khalid Al-Nedawi,M. Firoz Mian,Nazia Hossain,Khalil Karimi,Yu-Kang Mao,Paul Forsythe,Kevin K. Min,Andrew M. Stanisz,Wolfgang Kunze,John Bienenstock +9 more
TL;DR: Gut epithelial, but not direct neuronal application of, MVs replicated functional effects of JB‐1 on in situ patch‐clamped enteric neurons, suggesting the importance of epithelium neuron signaling and discrimination between pathways for bacteria‐neuron and ‐immune communication.