V
Vladimir Lhotak
Researcher at McMaster University
Publications - 4
Citations - 2276
Vladimir Lhotak is an academic researcher from McMaster University. The author has contributed to research in topics: Tumor progression & Cancer cell. The author has an hindex of 2, co-authored 3 publications receiving 2030 citations.
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Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
Khalid Al-Nedawi,Brian Meehan,Johann Micallef,Vladimir Lhotak,Linda May,Abhijit Guha,Janusz Rak +6 more
TL;DR: It is shown that EGFRvIII can be 'shared' between glioma cells by intercellular transfer of membrane-derived microvesicles ('oncosomes'), which can contribute to a horizontal propagation of oncogenes and their associated transforming phenotype among subsets of cancer cells.
Journal ArticleDOI
Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis.
Joanne L. Yu,Linda May,Vladimir Lhotak,Siranoush Shahrzad,Senji Shirasawa,Jeffrey I. Weitz,Brenda L. Coomber,Nigel Mackman,Janusz Rak +8 more
TL;DR: It is reported that in human colorectal cancer cells, TF expression is under control of 2 major transforming events driving disease progression, in a manner dependent on MEK/mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3'-kinase (PI3K).