K
Khalida Mokhtari
Researcher at University of Granada
Publications - 8
Citations - 225
Khalida Mokhtari is an academic researcher from University of Granada. The author has contributed to research in topics: Maslinic acid & Cancer. The author has an hindex of 5, co-authored 6 publications receiving 154 citations.
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Journal ArticleDOI
Maslinic acid, a triterpenic anti-tumoural agent, interferes with cytoskeleton protein expression in HT29 human colon-cancer cells.
Eva E. Rufino-Palomares,Fernando J. Reyes-Zurita,Leticia García-Salguero,Khalida Mokhtari,Pedro P. Medina,José A. Lupiáñez,Juan Peragón +6 more
TL;DR: This is the first evidence obtained of the regulatory effects of MA on the cytoskeleton, which may prove to be one of the bases of its anti-proliferative effect against colon-cancer cells.
Journal ArticleDOI
Anti-cancer and Anti-angiogenic Properties of Various Natural Pentacyclic Tri-terpenoids and Some of their Chemical Derivatives
Eva E. Rufino-Palomares,Amalia Pérez-Jiménez,Fernando J. Reyes-Zurita,Leticia Garcia Salguero,Khalida Mokhtari,Antonio Herrera-Merchan,Pedro P. Medina,Juan Peragón,José A. Lupiáñez +8 more
Journal ArticleDOI
Maslinic Acid, a Triterpene from Olive, Affects the Antioxidant and Mitochondrial Status of B16F10 Melanoma Cells Grown under Stressful Conditions
Khalida Mokhtari,Eva E. Rufino-Palomares,Amalia Pérez-Jiménez,Fernando J. Reyes-Zurita,Celeny Figuera,Leticia García-Salguero,Pedro P. Medina,Juan Peragón,José A. Lupiáñez +8 more
TL;DR: Maslinic acid had an antioxidant effect at lower assayed levels measured as DHR and antioxidant defense, however, at higher dosages MA induced cellular damage by apoptosis as seen in the results obtained.
Journal ArticleDOI
Target molecules in 3T3-L1 adipocytes differentiation are regulated by maslinic acid, a natural triterpene from Olea europaea
Amalia Pérez-Jiménez,Eva E. Rufino-Palomares,Nieves Fernández-Gallego,M. Carmen Ortuño-Costela,Fernando J. Reyes-Zurita,Juan Peragón,Leticia García-Salguero,Khalida Mokhtari,Pedro P. Medina,José A. Lupiáñez +9 more
TL;DR: MA has been demonstrated as potential antiadipogenic compound in 3T3-L1 cells and decreased lipid droplets and triglyceride levels, which is in concordance with the down-regulation of PPARγ and aP2.
Journal ArticleDOI
The oleanolic acid derivative, 3- O -succinyl-28- O -benzyl oleanolate, induces apoptosis in B16–F10 melanoma cells via the mitochondrial apoptotic pathway
Fernando J. Reyes-Zurita,Marta Medina-O'Donnell,Rosa M. Ferrer-Martín,Eva E. Rufino-Palomares,Samuel Martin-Fonseca,Francisco Rivas,Antonio Martínez,Andrés García-Granados,Amalia Pérez-Jiménez,Leticia García-Salguero,Juan Peragón,Khalida Mokhtari,Pedro P. Medina,Andrés Parra,José A. Lupiáñez +14 more
TL;DR: It is demonstrated for the first time that in melanoma cancer cells, compound 4 exerts a significant anti-proliferation effect by inducing the apoptotic process with mitochondrial depolarization.