Jetsumon Sattabongkot

TL;DR: In this article, the authors analyzed the K13-propeller sequence polymorphism in 14,037 samples collected in 59 countries in which malaria is endemic and identified 108 nonsynonymous K13 mutations, which showed marked geographic disparity in their frequency and distribution.

TL;DR: An imidazolopiperazine scaffold series was identified that was highly enriched among compounds active against Plasmodium liver stages and shows potent in vivo blood-stage therapeutic activity.

TL;DR: Loop-mediated isothermal amplification, a novel nucleic acid amplification method, was developed for the clinical detection of four species of human malaria parasites and may provide a simple and reliable test for routine screening for malaria parasites in both clinical laboratories and malaria clinics in areas where malaria is endemic.

TL;DR: Phenotypic heterogeneity in the repetitive portion of a human malaria circumsporozoite (CS) protein, a major target of candidate vaccines, has been found and implies that a P. vivax vaccine based on the CS protein repeat of one isolate will not be universally protective.

TL;DR: The changing malaria epidemiology in the GMS is reviewed, the vector systems and patterns of malaria transmission are analyzed, and the major challenges the malaria control community faces on its way to malaria elimination are identified.