K
Khyati Kapoor
Researcher at National Institutes of Health
Publications - 23
Citations - 864
Khyati Kapoor is an academic researcher from National Institutes of Health. The author has contributed to research in topics: ATP-binding cassette transporter & Binding site. The author has an hindex of 14, co-authored 23 publications receiving 728 citations. Previous affiliations of Khyati Kapoor include Great Ormond Street Hospital & Jawaharlal Nehru University.
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Book ChapterDOI
Multidrug resistance in yeast Candida.
Rajendra Prasad,Khyati Kapoor +1 more
TL;DR: The ABC transporters,CDR1, CDR2, and an MFS pump CaMDR1, play a key role in azole resistance as deduced from their high level of expression found in several azole-resistant clinical isolates.
Journal ArticleDOI
Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides.
Khyati Kapoor,Janet Finer-Moore,Bjørn Panyella Pedersen,Bjørn Panyella Pedersen,Laura Caboni,Andrew B. Waight,Roman C. Hillig,Peter Bringmann,Iring Heisler,Thomas Müller,Holger Siebeneicher,Robert M. Stroud +11 more
TL;DR: The first structure of WT-human glucose transporter 1 (hGLUT1), to the authors' knowledge, cocrystallized with inhibitors is reported, providing an important structural insight for the design of more selective inhibitors for hGLUTs and h GLUT1 in particular.
Journal ArticleDOI
Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1).
Eduardo E. Chufan,Khyati Kapoor,Hong-May Sim,Satyakam Singh,Tanaji T. Talele,Stewart R. Durell,Suresh A. Ambudkar +6 more
TL;DR: A large flexible pocket in the Pgp transmembrane domains is able to bind chemically diverse compounds and homology modeling of human Pgp and substrate and modulator docking studies support the biochemical and transport data.
Journal ArticleDOI
Drug-protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoprotein.
TL;DR: mutagenesis and molecular modeling studies of P-gp led to the identification of a pair of phenylalanine-tyrosine structural motifs in the transmembrane region that mediate the inhibition of ATP hydrolysis by certain drugs, with high affinity (IC50's ranging from 10 to 30nM).
Journal ArticleDOI
Phospholipidome of Candida: each species of Candida has distinctive phospholipid molecular species.
Ashutosh Singh,Tulika Prasad,Khyati Kapoor,Ajeet Mandal,Mary R. Roth,Ruth Welti,Rajendra Prasad +6 more
TL;DR: By employing electrospray ionization tandem mass spectrometry (ESI-MS/MS), the phospholipidomes of eight hemiascomycetous human pathogenic Candida species have been characterized and point to a typical molecular species imprint of Candida strains.