A
Ashutosh Singh
Researcher at University of Lucknow
Publications - 45
Citations - 1201
Ashutosh Singh is an academic researcher from University of Lucknow. The author has contributed to research in topics: Candida albicans & Mass spectrometry. The author has an hindex of 21, co-authored 43 publications receiving 956 citations. Previous affiliations of Ashutosh Singh include Jawaharlal Nehru University & United States Department of Veterans Affairs.
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Journal ArticleDOI
Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids
Visesato Mor,Antonella Rella,Amir M. Farnoud,Ashutosh Singh,Mansa Munshi,Arielle M. Bryan,Shamoon Naseem,James B. Konopka,Iwao Ojima,Erika E. Büllesbach,Alan Ashbaugh,Michael J. Linke,Michael J. Linke,Melanie T. Cushion,Melanie T. Cushion,Margaret S. Collins,Hari Krishna Ananthula,Larry Sallans,Pankaj B. Desai,Nathan P. Wiederhold,Annette W. Fothergill,William R. Kirkpatrick,Thomas F. Patterson,Lai Hong Wong,Sunita Sinha,Guri Giaever,Corey Nislow,Patrick Flaherty,Xuewen Pan,Gabriele Vargas Cesar,Patricia de Melo Tavares,Susana Frases,Kildare Miranda,Kildare Miranda,Marcio L. Rodrigues,Marcio L. Rodrigues,Chiara Luberto,Leonardo Nimrichter,Maurizio Del Poeta +38 more
TL;DR: Two compounds found were highly effective in vitro and in vivo against several pathogenic fungi and were well tolerated by animals and additive to current antifungals, suggesting that these drugs might pave the way for the development of a new class of antIFungals.
Journal ArticleDOI
Curcumin Targets Cell Wall Integrity via Calcineurin-Mediated Signaling in Candida albicans
Awanish Kumar,Sanjiveeni Dhamgaye,Indresh Kumar Maurya,Ashutosh Singh,Monika Sharma,Rajendra Prasad +5 more
TL;DR: In this article, the authors performed transcriptional profiling to identify the yet-unidentified targets of CUR in C. albicans and found that among 348 CUR-affected genes, 51 were upregulated and 297 were downregulated.
Journal ArticleDOI
Calcineurin Signaling and Membrane Lipid Homeostasis Regulates Iron Mediated MultiDrug Resistance Mechanisms in Candida albicans
TL;DR: The transcriptome and lipidome data provide the first novel insight into the intricate relationship between cellular iron, calcineurin signaling, membrane lipid homeostasis and drug susceptibility of Candida cells.
Journal ArticleDOI
Sphingolipids as targets for treatment of fungal infections.
Rodrigo Rollin-Pinheiro,Rodrigo Rollin-Pinheiro,Ashutosh Singh,Ashutosh Singh,Eliana Barreto-Bergter,Maurizio Del Poeta,Maurizio Del Poeta +6 more
TL;DR: This review aims to highlight the diverse strategies that could be used to block the synthesis or/and function of fungal sphingolipids.
Journal ArticleDOI
Comparative Lipidomics in Clinical Isolates of Candida albicans Reveal Crosstalk between Mitochondria, Cell Wall Integrity and Azole Resistance
TL;DR: This study illustrates how the gradual corrective changes in Candida lipidome correspond to the development of FLC tolerance and provides evidence of a cross-talk between mitochondrial lipid homeostasis, CW integrity and azole tolerance.