Kirk M. Druey

TL;DR: It is shown that PGE2 stimulates colon cancer cell growth through its heterotrimeric guanine nucleotide-binding protein (G protein)–coupled receptor, EP2, by a signaling route that involves the activation of phosphoinositide 3-kinase and the protein kinase Akt and relieving the inhibitory phosphorylation of β-catenin and activating its signaling pathway.

TL;DR: It is reported that RGS9,10 (for regulator of G-protein signalling) proteins are GAPs for Gα subunits, and these RGS proteins are likely to regulate a subset of the G- protein signalling pathways in mammalian cells.

TL;DR: Introducing RGS family members into yeast blunts signal transduction through the pheromone-response pathway and markedly impair MAP kinase activation by mammalian G-protein-linked receptors, indicating the existence and importance of an SST2-like desensitization mechanism in mammalian cells.

TL;DR: The ability to display ECV maps in units that are physiologically intuitive and may be interpreted on an absolute scale offers the potential for detection of diffuse disease and measurement of the extent and severity of abnormal regions.

TL;DR: This review highlights recent advances in the understanding of the physiological functions of one subfamily of RGS proteins with a high degree of homology (B/R4) gleaned from recent studies of knockout mice or cells with reduced RGS expression.