K
Kiyofumi Ninomiya
Researcher at Kindai University
Publications - 151
Citations - 4692
Kiyofumi Ninomiya is an academic researcher from Kindai University. The author has contributed to research in topics: Triterpene & Salacia. The author has an hindex of 36, co-authored 148 publications receiving 4121 citations. Previous affiliations of Kiyofumi Ninomiya include Kyoto Pharmaceutical University & Shujitsu University.
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Journal ArticleDOI
Carnosic acid, a new class of lipid absorption inhibitor from sage
Kiyofumi Ninomiya,Hisashi Matsuda,Hiroshi Shimoda,Norihisa Nishida,Naoki Kasajima,Tomoe Yoshino,Toshio Morikawa,Masayuki Yoshikawa +7 more
TL;DR: Carnosic acid significantly inhibited triglyceride elevation in olive oil-loaded mice at doses of 5-20 mg/kg (p.o.) and reduced the gain of body weight and the accumulation of epididymal fat weight in high fat diet-fed mice after 14 days.
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Inhibitory effect and action mechanism of sesquiterpenes from Zedoariae Rhizoma on D-galactosamine/lipopolysaccharide-induced liver injury.
TL;DR: Hepatoprotective sesquiterpenes were isolated from the aqueous acetone extract of Zedoariae Rhizoma, the rhizome of Curcuma zedoaria ROSCOE and found to show potent protective effect on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced acute liver injury in mice.
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Structures of new dammarane-type Triterpene Saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins.
TL;DR: Five new dammarane-type triterpene saponins, notoginsenosides-O, -P, -Q, -S, and -T, were isolated together with nine known protopanaxadiol oligoglycosides and elucidated on the basis of chemical and physicochemical evidence.
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Anti-hyperlipidemic sesquiterpenes and new sesquiterpene glycosides from the leaves of artichoke (Cynara scolymus L.): structure requirement and mode of action.
Hiroshi Shimoda,Kiyofumi Ninomiya,Norihisa Nishida,Tomoe Yoshino,Toshio Morikawa,Hisashi Matsuda,Masayuki Yoshikawa +6 more
TL;DR: The methanolic extract from the leaves of artichoke was found to suppress serum triglyceride elevation in olive oil-loaded mice and inhibition of gastric emptying was shown to be partly involved in anti-hyperlipidemic activity.
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Effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animals
Hisashi Matsuda,Yuhao Li,Toshiyuki Murakami,Kiyofumi Ninomiya,Johji Yamahara,Masayuki Yoshikawa +5 more
TL;DR: The relationship between their chemical structures and activities, the acyl groups in escins were essential and showed more potent activities than escin Ia which had both the 21-tigloyl group and the 2'-O-glucopyranosyl moiety.