K
Kiyoshi Takayama
Publications - 2
Citations - 79
Kiyoshi Takayama is an academic researcher. The author has contributed to research in topics: Ligand (biochemistry) & Transmembrane domain. The author has an hindex of 2, co-authored 2 publications receiving 56 citations.
Papers
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Journal ArticleDOI
Ligand binding to human prostaglandin E receptor EP 4 at the lipid-bilayer interface
Yosuke Toyoda,Yosuke Toyoda,Kazushi Morimoto,Ryoji Suno,Shoichiro Horita,Keitaro Yamashita,Kunio Hirata,Yusuke Sekiguchi,Satoshi Yasuda,Satoshi Yasuda,Mitsunori Shiroishi,Tomoko Shimizu,Yuji Urushibata,Yuta Kajiwara,Yuta Kajiwara,Tomoaki Inazumi,Yunhon Hotta,Hidetsugu Asada,Takanori Nakane,Yuki Shiimura,Tomoya Nakagita,Kyoshiro Tsuge,Suguru Yoshida,Tomoko Kuribara,Takamitsu Hosoya,Yukihiko Sugimoto,Yukihiko Sugimoto,Norimichi Nomura,Miwa Sato,Takatsugu Hirokawa,Takatsugu Hirokawa,Masahiro Kinoshita,Takeshi Murata,Kiyoshi Takayama,Masaki Yamamoto,Shuh Narumiya,Shuh Narumiya,So Iwata,Takuya Kobayashi,Takuya Kobayashi +39 more
TL;DR: A ligand-binding site at the interface of the lipid bilayer that is unique among GPCRs is revealed, which should facilitate the design of new therapeutic drugs targeting both orthosteric and allosteric sites in this receptor family.
Patent
Antibody against human prostaglandin e2 receptor ep4
TL;DR: In this paper, a monoclonal antibody that binds to a human PGE2 receptor subtype EP4 and inhibits the function of EP4 was used to suppress the intracellular cAMP level increase induced by EP4.