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Amanda B. Kuzma

Researcher at University of Pennsylvania

Publications -  35
Citations -  2378

Amanda B. Kuzma is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Genome-wide association study & Biology. The author has an hindex of 12, co-authored 24 publications receiving 1253 citations. Previous affiliations of Amanda B. Kuzma include Icahn School of Medicine at Mount Sinai.

Papers
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Journal ArticleDOI

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Rebecca Sims, +487 more
- 01 Sep 2017 - 
TL;DR: Three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease are observed, providing additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's Disease.
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Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis

Scott C. Neu, +24 more
- 01 Oct 2017 - 
TL;DR: Contrary to long-standing views, men and women with the APOE &egr;3/&egR;4 genotype have nearly the same odds of developing AD from age 55 to 85 years, but women have an increased risk at younger ages.
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New insights into the genetic etiology of Alzheimer’s disease and related dementias

Céline Bellenguez, +401 more
- 01 Apr 2022 - 
TL;DR: This paper performed a two-stage genome-wide association study with 111,326 clinically diagnosed/proxy AD cases and 677,663 controls and found 75 risk loci, of which 42 were new at the time of analysis.
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A statistical framework for cross-tissue transcriptome-wide association analysis.

Yiming Hu, +21 more
- 01 Mar 2019 - 
TL;DR: A summary-statistic-based testing framework that combines multiple single-tissue associations into a powerful metric to quantify the overall gene–trait association is described and applied to multiple genome-wide-association results.
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Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation

Joshua C. Bis, +118 more
- 01 Aug 2020 - 
TL;DR: The Alzheimer’s Disease Sequencing Project undertook whole exome sequencing in 5,740 late-onset Alzheimer disease cases and 5,096 cognitively normal controls primarily of European ancestry, identifying novel and predicted functional genetic variants in genes previously associated with AD.