Klaus W. Frommer

TL;DR: A database to prospectively gather key data of patients with SSc using a minimal essential dataset provides an abundance of information on the true clinical face of SSc that will be helpful in improving the classification of S Sc and its subsets and for developing more specific therapeutic recommendations.

TL;DR: The findings of the present study indicate that adiponectin induces gene expression and protein synthesis in human RASFs, lymphocytes, endothelial cells, and chondrocytes, supporting the concept of adip onectin being involved in the pathophysiologic modulation of RA effector cells.

TL;DR: The current knowledge about the influence of central adipokines in rheumatic diseases, highlighting several aspects of the role of adipokine in chronic inflammation, is summarized.

TL;DR: Current knowledge relating to adipokines in rheumatic diseases is summarized, with a particular focus on the effects of adipokine on bone remodelling.

TL;DR: The data show that FFA are not only metabolic substrates but may also directly contribute to articular inflammation and degradation in inflammatory joint diseases and require extracellular and intracellular access to the TLR4 receptor complex.