K
Koen van der Maaden
Researcher at Leiden University
Publications - 34
Citations - 1492
Koen van der Maaden is an academic researcher from Leiden University. The author has contributed to research in topics: Drug delivery & Cationic liposome. The author has an hindex of 16, co-authored 34 publications receiving 1147 citations. Previous affiliations of Koen van der Maaden include Leiden University Medical Center.
Papers
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Journal ArticleDOI
Comprehensive evaluation of microneedle-based intradermal adalimumab delivery vs. subcutaneous administration: results of a randomized controlled clinical trial
Justin Jacobse,Wouter ten Voorde,Anushka Tandon,Stefan Romeijn,Hendrika W. Grievink,Koen van der Maaden,Michiel J van Esdonk,Dirk Jan A.R. Moes,Floris C. Loeff,Karien Bloem,Annick de Vries,Theo Rispens,Gertjan Wolbink,Marieke de Kam,Dimitrios Ziagkos,Matthijs Moerland,Wim Jiskoot,Joke A. Bouwstra,Jacobus Burggraaf,Lenneke Schrier,Robert Rissmann,Robert Rissmann,Rebecca ten Cate +22 more
TL;DR: In this article, the authors evaluated feasibility of intradermal (i.d.) adalimumab administration using hollow microneedles, and compared a single i.d. dose with a single subcutaneous (s.c.) dose using a conventional needle.
Journal ArticleDOI
Evaluation of the high-pressure extrusion technique as a method for sizing plasmid DNA-containing cationic liposomes
Myrra G. Carstens,Koen van der Maaden,Daniël van der Velden,Tom H. M. Ottenhoff,Cornelis J. M. Melief,Ferry Ossendorp,Joke A. Bouwstra,Wim Jiskoot +7 more
TL;DR: High-pressure extrusion is a suitable technique to size cationic liposomes with entrapped pDNA and allows preparation of well-defined nanosized pDNA-liposomes, with preserved pDNA integrity.
Journal ArticleDOI
Engineering of an automated nano-droplet dispensing system for fabrication of antigen-loaded dissolving microneedle arrays
TL;DR: In this article, a reproducible fabrication method for dissolving microneedle arrays (dMNAs) based on an automated nano-droplet dispensing system that minimizes antigen waste was developed.
Microneedle-mediated vaccine delivery
TL;DR: Several fundamental parameters that influence skin penetration by microneedles as well as factors that affect antigen-specific immune responses in animals following micronedle-based vaccination are described, providing important new insights for enabling pain free vaccination via the skin.
Patent
Process and device for minimally invasive deep tissue probing.
Koen van der Maaden,Sebastiaan Johannes Trietsch,Heiko J. van der Linden,Johanna Aaltje Bouwstra,Thomas Hankemeier +4 more
TL;DR: In this paper, an ultra-high aspect ratio needle cannula with pointed, tissue penetrating distal end for deep tissue probing was presented, having an inner diameter in the range of from 5 to 50 pm, an outer diameter of from 50 to 2500 pm, and an aspect ratio of the width 1/1/ measured at the tip of the pointed distal ends to the length L measured from the tip to the beginning of a continuous contraction of the outer diameter.