Bhushan S. Pattni,† Vladimir V. Chupin,‡ and Vladimir P. Torchilin*,†,§,∥ †Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, Massachusetts 02115, United States ‡Laboratory for Advanced Studies of Membrane Proteins, Moscow Institute of Physics and Technology, Dolgoprudny 141700, Russia Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia

New Developments in Liposomal Drug Delivery.

Polylactic acid (PLA) controlled delivery carriers for biomedical applications.

The skin offers an accessible and convenient site for the administration of medications. To this end, the field of transdermal drug delivery, aimed at developing safe and efficacious means of delivering medications across the skin, has in the past and continues to garner much time and investment with the continuous advancement of new and innovative approaches. This review details the progress and current status of the transdermal drug delivery field and describes numerous pharmaceutical developments which have been employed to overcome limitations associated with skin delivery systems. Advantages and disadvantages of the various approaches are detailed, commercially marketed products are highlighted and particular attention is paid to the emerging field of microneedle technologies.

https://www.mdpi.com/1999-4923/7/4/438/pdf

Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum

Microneedles: A smart approach and increasing potential for transdermal drug delivery system.

Insulin is essential for type 1 and advanced type 2 diabetics to maintain blood glucose levels and prolong lives. The traditional administration requires frequent subcutaneous insulin injections that are associated with poor patient compliance, including pain, local tissue necrosis, infection, and nerve damage. Taking advantage of emerging micro- and nanotechnologies, numerous alternative strategies integrated with chemical approaches for insulin delivery have been investigated. This review outlines recent developments in the controlled delivery of insulin, including oral, nasal, pulmonary, transdermal, subcutaneous and closed-loop insulin delivery. Perspectives from new materials, formulations and devices at the micro- or nano-scales are specifically surveyed. Advantages and limitations of current delivery methods, as well as future opportunities and challenges are also discussed.

Emerging micro- and nanotechnology based synthetic approaches for insulin delivery

https://scholarlypublications.universiteitleiden.nl/access/item%3A2950337/view

Hollow microneedle-mediated micro-injections of a liposomal HPV E7(43-63) synthetic long peptide vaccine for efficient induction of cytotoxic and T-helper responses

https://pure.tue.nl/ws/files/73225468/schidiph2017.pdf

Diphtheria toxoid and N-trimethyl chitosan layer-by-layer coated pH-sensitive microneedles induce potent immune responses upon dermal vaccination in mice

Cancer immunotherapy has shown remarkable progress in recent years. Nanocarriers, such as liposomes, have favorable advantages with the potential to further improve cancer immunotherapy and even stronger immune responses by improving cell type-specific delivery and enhancing drug efficacy. Liposomes can offer solutions to common problems faced by several cancer immunotherapies, including the following: (1) Vaccination: Liposomes can improve the delivery of antigens and other stimulatory molecules to antigen-presenting cells or T cells; (2) Tumor normalization: Liposomes can deliver drugs selectively to the tumor microenvironment to overcome the immune-suppressive state; (3) Rewiring of tumor signaling: Liposomes can be used for the delivery of specific drugs to specific cell types to correct or modulate pathways to facilitate better anti-tumor immune responses; (4) Combinational therapy: Liposomes are ideal vehicles for the simultaneous delivery of drugs to be combined with other therapies, including chemotherapy, radiotherapy, and phototherapy. In this review, different liposomal systems specifically developed for immunomodulation in cancer are summarized and discussed.

Liposome-Based Drug Delivery Systems in Cancer Immunotherapy.

Microneedles are needle-like structures shorter than 1 mm that have been advocated as devices for enabling potentially pain-free intradermal delivery of biomacromolecules (1–5). To permit a reproducible delivery of the drug, microneedles should be inserted into the skin in a controlled and reproducible manner (4,6). Obviously, one of the factors that influence the penetration ability of microneedles is the insertion process itself, e.g., microneedles can be inserted manually or by using insertion devices (3,4,6–9). Recently, the penetration ability of low-density arrays (42 microneedles/cm2) with 750-μm long microneedles, applied manually or by using a snap-based applicator, was investigated (10). However, no studies have been reported on the efficiency and reproducibility of the insertion of high-density microneedles into human skin. Therefore, the aim of this study was to investigate the effect of the type of application on inter and intra individual variability of microneedle insertion into human skin by microneedle users.

We show that participants using an impact-insertion applicator inserted high-density microneedles into ex vivo human skin with high efficiency and with a low inter and intra individual variation. However, when the same microneedle arrays were inserted by using a manual insertion device, the penetration efficiency was reduced by approximately 40% with a considerably lower reproducibility. Finally, the applicability of an impact-insertion applicator/microneedle array was confirmed in a vaccination study in mice.

/pdf/impact-insertion-applicator-improves-reliability-of-skin-1k75oae05s.pdf

Koen van der Maaden

Papers

Hollow microneedle-mediated micro-injections of a liposomal HPV E7(43-63) synthetic long peptide vaccine for efficient induction of cytotoxic and T-helper responses

Diphtheria toxoid and N-trimethyl chitosan layer-by-layer coated pH-sensitive microneedles induce potent immune responses upon dermal vaccination in mice

Liposome-Based Drug Delivery Systems in Cancer Immunotherapy.

Impact-insertion applicator improves reliability of skin penetration by solid microneedle arrays.

Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies.