K
Kostas A. Papavassiliou
Researcher at National and Kapodistrian University of Athens
Publications - 40
Citations - 965
Kostas A. Papavassiliou is an academic researcher from National and Kapodistrian University of Athens. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 11, co-authored 21 publications receiving 629 citations.
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Journal ArticleDOI
Mechanotransduction in osteoblast regulation and bone disease.
Katerina K. Papachroni,Demetrios N. Karatzas,Kostas A. Papavassiliou,Efthimia K. Basdra,Athanasios G. Papavassiliou +4 more
TL;DR: The molecular pathways and players activated by mechanical stimulation during osteoblastic growth, differentiation and activity in health are reviewed, and the role of mechanostimulatory approaches in treating various bone pathophysiologies is considered.
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Redox and NF-κB signaling in osteoarthritis.
TL;DR: Osteoarthritis is the most common joint disorder with a multi‐factorial etiology including overproduction of ROS, and ROS overproduction in OA modifies intracellular signaling, chondrocyte life cycle, metabolism of cartilage matrix and contributes to synovial inflammation and dysfunction of the subchondral bone.
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Transcription Factor Drug Targets
TL;DR: Recent advances regarding the significance of transcription factors in human diseases are summarized and emerging pharmacological strategies to modulate transcription factor function are discussed.
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Role of Histone Lysine Methyltransferases SUV39H1 and SETDB1 in Gliomagenesis: Modulation of Cell Proliferation, Migration, and Colony Formation
Anastasia Spyropoulou,Antonios N. Gargalionis,Georgia Dalagiorgou,Christos Adamopoulos,Kostas A. Papavassiliou,Robert W. Lea,Christina Piperi,Athanasios G. Papavassiliou +7 more
TL;DR: Both HKMTs and especially SUV39H1 may serve as novel biomarkers for future therapeutic targeting of these tumors, and results indicate overexpression of SETDB1 and SUV39h1 in gliomas.
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Hydrogen bonds in protein-DNA complexes: where geometry meets plasticity.
Stavroula A. Coulocheri,Diomidis G. Pigis,Kostas A. Papavassiliou,Athanasios G. Papavassiliou +3 more
TL;DR: The prominent elements in the recognition of a particular DNA sequence by a protein are the hydrogen-bond donors and acceptors of the base pairs into the grooves of the DNA that must interact with complementary moieties of the protein partner.