K
Kozo Ochi
Researcher at Hiroshima Institute of Technology
Publications - 166
Citations - 7870
Kozo Ochi is an academic researcher from Hiroshima Institute of Technology. The author has contributed to research in topics: Mutant & Streptomyces coelicolor. The author has an hindex of 49, co-authored 163 publications receiving 7359 citations. Previous affiliations of Kozo Ochi include Coventry Health Care & Astellas Pharma.
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Journal ArticleDOI
Structural Basis for Transcription Regulation by Alarmone ppGpp
Irina Artsimovitch,Vsevolod Patlan,Shun-ichi Sekine,Marina N. Vassylyeva,Takeshi Hosaka,Kozo Ochi,Shigeyuki Yokoyama,Dmitry G. Vassylyev +7 more
TL;DR: The results suggest that base pairing of ppGpp with cytosines in the nontemplate DNA strand might be an essential component of transcription control by pGuanosine-tetraphosphate.
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Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria.
Susumu Okamoto,Aki Tamaru,Chie Nakajima,Kenji Nishimura,Yukinori Tanaka,Shinji Tokuyama,Yasuhiko Suzuki,Kozo Ochi +7 more
TL;DR: GidB is identified as a new streptomycin‐resistance locus and a resistance mechanism that is mediated by loss of a conserved m7G modification in 16S rRNA is uncovered, which may provide a basis for developing strategies to suppress pathogenic bacteria, including M. tuberculosis.
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Polyketide Synthase Gene Coupled to the Peptide Synthetase Module Involved in the Biosynthesis of the Cyclic Heptapeptide Microcystin
Tomoyasu Nishizawa,Akiko Ueda,Munehiko Asayama,Kiyonaga Fujii,Ken-ichi Harada,Kozo Ochi,Makoto Shirai +6 more
TL;DR: The mcyDEFG operon is presumed to be responsible for 3-amino-9-methoxy-2,6, 8-trimethyl-10-phenyldeca-4,6-dienoic acid (Adda) biosynthesis, and the incorporation of Adda and glutamic acid into the microcystin molecule.
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New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters
Kozo Ochi,Takeshi Hosaka +1 more
TL;DR: In this paper, the authors review current progress on this topic, describing concepts for activating silent genes, utilization of mutant-type RNA polymerases and rare earth elements, and the applicability of ribosome engineering to myxobacteria and fungi.
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Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2).
TL;DR: Results indicate that the onset and extent of secondary metabolism in Streptomyces spp.