K
Krasimir Kolev
Researcher at Semmelweis University
Publications - 73
Citations - 1929
Krasimir Kolev is an academic researcher from Semmelweis University. The author has contributed to research in topics: Plasmin & Fibrin. The author has an hindex of 21, co-authored 66 publications receiving 1608 citations.
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Journal ArticleDOI
Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones
Colin Longstaff,Imre Varjú,Péter Sótonyi,László Szabó,Michael Krumrey,Armin Hoell,Attila Bóta,Zoltán Varga,Erzsébet Komorowicz,Krasimir Kolev +9 more
TL;DR: It is demonstrated that the addition of histone-DNA complexes to fibrin results in thicker fibers accompanied by improved stability and rigidity, and Therapeutic strategies could be optimized to enhance fibrinolysis in clots containing DNA and histones.
Journal ArticleDOI
The interplay between tissue plasminogen activator domains and fibrin structures in the regulation of fibrinolysis: kinetic and microscopic studies.
Colin Longstaff,Craig Thelwell,Stella C. Williams,Marta M.C.G. Silva,László Szabó,Krasimir Kolev +5 more
TL;DR: TPA structure/function relationships were investigated in fibrin formed by high or low thrombin concentrations to produce a fine mesh and small pores, or thick fibers and coarse structure, respectively, showing that tPA was strongly associated with agglomerates in coarse but not in finefibrin.
Journal ArticleDOI
DNA, histones and neutrophil extracellular traps exert anti-fibrinolytic effects in a plasma environment:
Imre Varjú,Colin Longstaff,László Szabó,Á. Farkas,Veronika Judit Varga-Szabó,Anna Tanka-Salamon,Raymund Machovich,Krasimir Kolev +7 more
TL;DR: It is shown that DNA and histones alter the fibrin architecture in plasma clots, while NETs contribute to a decreased lytic susceptibility that can be overcome by DNase.
Journal ArticleDOI
Lytic Resistance of Fibrin-Containing Red Blood Cells
Nikolett Wohner,Péter Sótonyi,Raymund Machovich,László Szabó,Kiril Tenekedjiev,Marta M.C.G. Silva,Colin Longstaff,Krasimir Kolev +7 more
TL;DR: RBCs confer lytic resistance to fibrin resulting from modifiedfibrin structure and impaired plasminogen activation through a mechanism that involves eptifibatide-sensitive fibr inogen-RBC interactions.
Journal ArticleDOI
Neutrophils and neutrophil extracellular traps enhance venous thrombosis in mice bearing human pancreatic tumors
Yohei Hisada,Steven P. Grover,Anaum Maqsood,Reaves Houston,Cihan Ay,Denis F. Noubouossie,Brian C. Cooley,Håkan Wallén,Nigel S. Key,Charlotte Thålin,Á. Farkas,Veronika J. Farkas,Kiril Tenekedjiev,Krasimir Kolev,Nigel Mackman +14 more
TL;DR: The results, together with clinical data, suggest that neutrophils and NET contribute to venous thrombosis in patients with pancreatic cancer.