Krishna Prasadan

TL;DR: Blocking early expression and function of glucagon, but not GLP-1, an alternate gene product of preproglucagon mRNA, prevented insulin-positive differentiation in early embryonic (E11) pancreas, suggesting a novel concept and a key role for glucagon in the paracrine induction of differentiation of other pancreatic components in the early embryonic Pancreas.

TL;DR: It is found that, in a co-culture system, NIH3T3 cells were able to substitute for mesenchyme in exocrine induction as well as in both the endocrine induction and endocrine inhibition, implying that the responsible molecules are not unique to pancreatic mesenchYme.

TL;DR: BMP signaling may represent a novel downstream target of exendin-4 (glucagon-like peptide 1) signaling and potentially serve as an upstream regulator of transforming growth factor-β isoform signaling to differentiate the acinar-like AR42J cells into insulin-secreting cells.

TL;DR: Retinoids regulate exocrine lineage selection through epithelial-mesenchyme interactions, mediated through up-regulation of mesenchymal laminin-1.

TL;DR: DBA detects specifically epithelial, but neither differentiating endocrine cells nor acinar cells, which could be applied to study differentiation and cell lineage selections in the developing pancreas and also may be applicable to selecting pancreatic precursor cells for potential cellular engineering.