抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Topological insulators are new states of quantum matter which cannot be adiabatically connected to conventional insulators and semiconductors. They are characterized by a full insulating gap in the bulk and gapless edge or surface states which are protected by time-reversal symmetry. These topological materials have been theoretically predicted and experimentally observed in a variety of systems, including HgTe quantum wells, BiSb alloys, and Bi2Te3 and Bi2Se3 crystals. Theoretical models, materials properties, and experimental results on two-dimensional and three-dimensional topological insulators are reviewed, and both the topological band theory and the topological field theory are discussed. Topological superconductors have a full pairing gap in the bulk and gapless surface states consisting of Majorana fermions. The theory of topological superconductors is reviewed, in close analogy to the theory of topological insulators.

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Topological insulators and superconductors

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Table Of Integrals Series And Products

Topological photonics is a rapidly emerging field of research in which geometrical and topological ideas are exploited to design and control the behavior of light. Drawing inspiration from the discovery of the quantum Hall effects and topological insulators in condensed matter, recent advances have shown how to engineer analogous effects also for photons, leading to remarkable phenomena such as the robust unidirectional propagation of light, which hold great promise for applications. Thanks to the flexibility and diversity of photonics systems, this field is also opening up new opportunities to realize exotic topological models and to probe and exploit topological effects in new ways. This article reviews experimental and theoretical developments in topological photonics across a wide range of experimental platforms, including photonic crystals, waveguides, metamaterials, cavities, optomechanics, silicon photonics, and circuit QED. A discussion of how changing the dimensionality and symmetries of photonics systems has allowed for the realization of different topological phases is offered, and progress in understanding the interplay of topology with non-Hermitian effects, such as dissipation, is reviewed. As an exciting perspective, topological photonics can be combined with optical nonlinearities, leading toward new collective phenomena and novel strongly correlated states of light, such as an analog of the fractional quantum Hall effect.

Topological Photonics

It is demonstrated that an isolated generic quantum many-body system does relax to a state well described by the standard statistical mechanical prescription The thermalization happens at the level of individual eigenstates, allowing the computation of thermal averages from knowledge of any eigenstate in the microcanonical energy window An understanding of the temporal evolution of isolated many-body quantum systems has long been elusive Recently, meaningful experimental studies1,2 of the problem have become possible, stimulating theoretical interest3,4,5,6,7 In generic isolated systems, non-equilibrium dynamics is expected8,9 to result in thermalization: a relaxation to states in which the values of macroscopic quantities are stationary, universal with respect to widely differing initial conditions, and predictable using statistical mechanics However, it is not obvious what feature of many-body quantum mechanics makes quantum thermalization possible in a sense analogous to that in which dynamical chaos makes classical thermalization possible10 For example, dynamical chaos itself cannot occur in an isolated quantum system, in which the time evolution is linear and the spectrum is discrete11 Some recent studies4,5 even suggest that statistical mechanics may give incorrect predictions for the outcomes of relaxation in such systems Here we demonstrate that a generic isolated quantum many-body system does relax to a state well described by the standard statistical-mechanical prescription Moreover, we show that time evolution itself plays a merely auxiliary role in relaxation, and that thermalization instead happens at the level of individual eigenstates, as first proposed by Deutsch12 and Srednicki13 A striking consequence of this eigenstate-thermalization scenario, confirmed for our system, is that knowledge of a single many-body eigenstate is sufficient to compute thermal averages—any eigenstate in the microcanonical energy window will do, because they all give the same result

Thermalization and its mechanism for generic isolated quantum systems

This Colloquium gives an overview of recent theoretical and experimental progress in the area of nonequilibrium dynamics of isolated quantum systems There is particularly a focus on quantum quenches: the temporal evolution following a sudden or slow change of the coupling constants of the system Hamiltonian Several aspects of the slow dynamics in driven systems are discussed and the universality of such dynamics in gapless systems with specific focus on dynamics near continuous quantum phase transitions is emphasized Recent progress on understanding thermalization in closed systems through the eigenstate thermalization hypothesis is also reviewed and relaxation in integrable systems is discussed Finally key experiments probing quantum dynamics in cold atom systems are overviewed and put into the context of our current theoretical understanding

Colloquium: Nonequilibrium dynamics of closed interacting quantum systems

For certain orientations of Josephson junctions between two px-wave or two d-wave superconductors, the subgap Andreev bound states produce a \(4\pi\)-periodic relation between the Josephson current I and the phase difference \(\phi\): \(I\propto\sin(\phi/2)\) Consequently, the ac Josephson current has the fractional frequency \(eV/\hbar\), where V is the dc voltage In the tunneling limit, the Josephson current is proportional to the first power (not square) of the electron tunneling amplitude Thus, the Josephson current between unconventional superconductors is carried by single electrons, rather than by Cooper pairs The fractional ac Josephson effect can be observed experimentally by measuring frequency spectrum of microwave radiation from the junction We also study junctions between singlet s-wave and triplet px-wave, as well as between chiral \(p_x\pm ip_y\)-wave superconductors

Fractional ac Josephson effect in p- and d-wave superconductors

We study the quantum dynamics of a number of model systems as their coupling constants are changed rapidly across a quantum critical point. The primary motivation is provided by the recent experiments of Greiner et al. [Nature (London) 415, 39 (2002)] who studied the response of a Mott insulator of ultracold atoms in an optical lattice to a strong potential gradient. In a previous work, it had been argued that the resonant response observed at a critical potential gradient could be understood by proximity to an Ising quantum critical point describing the onset of density wave order. Here we obtain numerical results on the evolution of the density wave order as the potential gradient is scanned across the quantum critical point. This is supplemented by studies of the integrable quantum Ising spin chain in a transverse field, where we obtain exact results for the evolution of the Ising order correlations under a time-dependent transverse field. We also study the evolution of transverse superfluid order in the three-dimensional case. In all cases, the order parameter is best enhanced in the vicinity of the quantum critical point.

Quench dynamics across quantum critical points

We describe the zero-temperature phase diagram of a model of bosons, occupying sites of a linear chain, which obey a hard-exclusion constraint: any two nearest-neighbor sites may have at most one boson. A special case of our model was recently proposed as a description of a ``tilted'' Mott insulator of atoms trapped in an optical lattice. Our quantum Hamiltonian is shown to generate the transfer matrix of Baxter's hard-square model. Aided by exact solutions of a number of special cases, and by numerical studies, we obtain a phase diagram containing states with long-range density-wave order with periods 2 and 3, and also a floating incommensurate phase. Critical theories for the various quantum phase transitions are presented. As a byproduct, we show how to compute the Luttinger parameter in integrable theories with hard-exclusion constraints.

https://arxiv.org/pdf/cond-mat/0309438.pdf

Competing density-wave orders in a one-dimensional hard-boson model

For certain orientations of Josephson junctions between two px-wave or two d-wave superconductors, the subgap Andreev bound states produce a \(4\pi\)-periodic relation between the Josephson current I and the phase difference \(\phi\): \(I\propto\sin(\phi/2)\). Consequently, the ac Josephson current has the fractional frequency \(eV/\hbar\), where V is the dc voltage. In the tunneling limit, the Josephson current is proportional to the first power (not square) of the electron tunneling amplitude. Thus, the Josephson current between unconventional superconductors is carried by single electrons, rather than by Cooper pairs. The fractional ac Josephson effect can be observed experimentally by measuring frequency spectrum of microwave radiation from the junction. We also study junctions between singlet s-wave and triplet px-wave, as well as between chiral \(p_x\pm ip_y\)-wave superconductors.

Krishnendu Sengupta

Papers

Colloquium: Nonequilibrium dynamics of closed interacting quantum systems

Fractional ac Josephson effect in p- and d-wave superconductors

Quench dynamics across quantum critical points

Competing density-wave orders in a one-dimensional hard-boson model

Fractional ac Josephson effect in p- and d-wave superconductors