K
Kristen A. Murphy
Researcher at Duke University
Publications - 3
Citations - 7
Kristen A. Murphy is an academic researcher from Duke University. The author has contributed to research in topics: Proinflammatory cytokine & Interferon. The author has co-authored 3 publications.
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Journal ArticleDOI
FTO Suppresses STAT3 Activation and Modulates Proinflammatory Interferon-Stimulated Gene Expression
Michael J. McFadden,Matthew T. Sacco,Kristen A. Murphy,Moonhee Park,Nandan S. Gokhale,Kim Y. Somfleth,Stacy M. Horner +6 more
TL;DR: In this article, the role of the RNA demethylase fat mass and obesity-associated protein (FTO) in the type I IFN response was determined, and it was shown that depletion of FTO led to activation of the transcription factor STAT3, which increased the expression of a subset of ISGs.
Posted ContentDOI
FTO suppresses STAT3 activation and modulates proinflammatory interferon-stimulated gene expression
Michael J. McFadden,Matthew T. Sacco,Kristen A. Murphy,Moonhee Park,Nandan S. Gokhale,Kim Y. Somfleth,Stacy M. Horner +6 more
TL;DR: In this paper, the role of RNA demethylase FTO in the type I interferon response is determined, and it is shown that depletion of FTO led to activation of STAT3, a transcription factor that mediates responses to various cytokines, but whose role in the IFN response is not well understood.
Posted ContentDOI
Signaling from the RNA sensor RIG-I is regulated by ufmylation
TL;DR: In this article, the authors show that UFL1, as well as the process of ufmylation, promote IFN induction in response to RIG-I activation.