K
Krister Wennerberg
Researcher at University of Copenhagen
Publications - 205
Citations - 14023
Krister Wennerberg is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Cancer & Myeloid leukemia. The author has an hindex of 50, co-authored 179 publications receiving 11569 citations. Previous affiliations of Krister Wennerberg include Southern Research Institute & University of Helsinki.
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Journal ArticleDOI
Rho and Rac Take Center Stage
TL;DR: This work will describe how the activity of Rho proteins is regulated downstream from growth factor receptors and cell adhesion molecules by guanine nucleotide exchange factors and GTPase activating proteins.
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The Ras superfamily at a glance.
TL;DR: The Ras superfamily of small guanosine triphosphatases (GTPases) comprise over 150 human members, with evolutionarily conserved orthologs found in Drosophila, C. elegans, S. cerevisiae, Dictyostelium and plants.
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Rho-family GTPases: it's not only Rac and Rho (and I like it).
TL;DR: The Rho-family proteins make up a major branch of the Ras superfamily of small GTPases, and newer members of the family possess additional sequence elements beyond the GTPase domain, which suggests they exhibit yet other mechanisms of regulation.
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Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia
Hanna Koskela,Samuli Eldfors,Pekka Ellonen,Arjan J. van Adrichem,Heikki Kuusanmäki,Emma I. Andersson,Sonja Lagström,Michael J. Clemente,Thomas L. Olson,Sari E. Jalkanen,Muntasir Mamun Majumder,Henrikki Almusa,Henrik Edgren,Maija Lepistö,Pirkko Mattila,Kathryn M Guinta,Pirjo Koistinen,Taru Kuittinen,Kati Penttinen,Alun Parsons,Jonathan Knowles,Janna Saarela,Krister Wennerberg,Olli Kallioniemi,Kimmo Porkka,Thomas P. Loughran,Caroline A. Heckman,Jaroslaw P. Maciejewski,Satu Mustjoki +28 more
TL;DR: The SH2 dimerization and activation domain of STAT3 is frequently mutated in patients with large granular lymphocytic leukemia; these findings suggest that aberrant STAT3 signaling underlies the pathogenesis of this disease.
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Integrin signaling to the actin cytoskeleton.
TL;DR: Integrin engagement stimulates the activity of numerous signaling molecules, including the Rho family of GTPases, tyrosine phosphatases, cAMP-dependent protein kinases and protein kinase C, and stimulates production of PtdIns(4,5)P2.