K
Kristopher Dennis
Researcher at University of Ottawa
Publications - 106
Citations - 3027
Kristopher Dennis is an academic researcher from University of Ottawa. The author has contributed to research in topics: Palliative care & Radiation therapy. The author has an hindex of 19, co-authored 91 publications receiving 2495 citations. Previous affiliations of Kristopher Dennis include Ottawa Hospital Research Institute & Ottawa Hospital.
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Journal ArticleDOI
Antiemetics: American Society of Clinical Oncology Clinical Practice Guideline Update
Paul J. Hesketh,Mark G. Kris,Ethan Basch,Kari Bohlke,Sally Y. Barbour,Rebecca Clark-Snow,Michael A. Danso,Kristopher Dennis,L. Lee Dupuis,Stacie B. Dusetzina,Cathy Eng,Petra Feyer,Karin Jordan,Kimberly Noonan,Dee Sparacio,Mark R. Somerfield,Gary H. Lyman +16 more
TL;DR: The Update Committee noted the importance of continued symptom monitoring throughout therapy, and Clinicians underestimate the incidence of nausea, which is not as well controlled as emesis.
Journal ArticleDOI
Update on the systematic review of palliative radiotherapy trials for bone metastases
TL;DR: Overall and complete response rates were similar in both intention-to-treat and assessable patients, and single and multiple fraction regimens provided equal pain relief; however, significantly higher retreatment rates occurred in those receiving single fractions.
Journal ArticleDOI
Antiemetics: ASCO Guideline Update.
Paul J. Hesketh,Mark G. Kris,Ethan Basch,Kari Bohlke,Sally Y. Barbour,Rebecca Clark-Snow,Michael A. Danso,Kristopher Dennis,Kristopher Dennis,L. Lee Dupuis,Stacie B. Dusetzina,Cathy Eng,Petra Feyer,Karin Jordan,Kimberly Noonan,Dee Sparacio,Gary H. Lyman +16 more
TL;DR: There is no clinical evidence to warrant omission of dexamethasone from guideline-compliant prophylactic antiemetic regimens when CPIs are administered to adults in combination with chemotherapy.
Journal ArticleDOI
Dexamethasone in the prophylaxis of radiation-induced pain flare after palliative radiotherapy for bone metastases: a double-blind, randomised placebo-controlled, phase 3 trial
Edward Chow,Ralph M. Meyer,Keyue Ding,Abdenour Nabid,Pierre Chabot,Philip Wong,Shahida Ahmed,Joda Kuk,A. Rashid Dar,Aamer Mahmud,Alysa Fairchild,Carolyn F. Wilson,Jackson S.Y. Wu,Kristopher Dennis,Michael Brundage,Carlo DeAngelis,Rebecca Wong +16 more
TL;DR: In this paper, the authors compared the efficacy of dexamethasone with that of placebo in terms of reduction of incidence of pain flare after palliative radiotherapy, and showed that the latter drug significantly reduced the number of pain flares.
Journal ArticleDOI
Effect of Radiotherapy on Painful Bone Metastases: A Secondary Analysis of the NCIC Clinical Trials Group Symptom Control Trial SC.23
Rachel McDonald,Keyue Ding,Michael Brundage,Ralph M. Meyer,Abdenour Nabid,Pierre Chabot,Genevieve Coulombe,Shahida Ahmed,Joda Kuk,A. Rashid Dar,Aamer Mahmud,Alysa Fairchild,Carolyn F. Wilson,Jackson S.Y. Wu,Kristopher Dennis,Carlo DeAngelis,Rebecca Wong,Liting Zhu,Stephanie Chan,Edward Chow +19 more
TL;DR: Forty percent of patients experienced pain reduction and better QOL at day 10 after radiotherapy with further improvements in Qol at day 42 in responders, suggesting a single 8-Gy radiotherapy dose for bone metastases should be offered to all patients, even those with poor survival.