Kristy M. McClellan

TL;DR: This work reviews the processes involved in forming a functional nuclear group and some of the factors known to be involved particularly focusing on the positioning of identified neurons within the VMH.

TL;DR: Sex differences in cell positions in the developing hypothalamus, and steroid hormone influences on cell movements in vitro, suggest that cell migration may be one target for early molecular actions that impact brain development and sexual differentiation.

TL;DR: Support is provided for the suggestion that sex differences in cellular organization in the developing hypothalamus arise from sex differencesIn animals that were genetically deprived of gonadal and adrenal hormones by virtue of a disrupted gene coding for steroidogenic factor 1, cells containing ir ERbeta followed a female phenotype for location at E17 and afemale phenotype for number of ir cells at P0 regardless of genetic sex, suggesting that circulating hormones may be influencing cell position in the POA/AH.

TL;DR: It is concluded that GABA alters cell migration and its effect on final cell positioning may lead to changes in the circuitry and connections within specific nuclei of the developing hypothalamus.

TL;DR: Data from mice revealed Snord116 expression in the medial hypothalamus, particularly within nuclei that are part of feeding circuitry, which provides a new lead for understanding the mechanism(s) related to hyperphagia and obesity symptoms in PWS patients.