K
Kumar Dharmarajan
Researcher at Yale University
Publications - 106
Citations - 7667
Kumar Dharmarajan is an academic researcher from Yale University. The author has contributed to research in topics: Heart failure & Myocardial infarction. The author has an hindex of 31, co-authored 103 publications receiving 6560 citations. Previous affiliations of Kumar Dharmarajan include Peking Union Medical College & Harvard University.
Papers
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Journal ArticleDOI
Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy
Sue C. Bodine,Esther Latres,Susanne Baumhueter,Venus Lai,Lorna Nunez,Brian A. Clarke,William Poueymirou,Frank J. Panaro,Erqian Na,Kumar Dharmarajan,Zhen-Qiang Pan,David M. Valenzuela,Thomas M. DeChiara,Trevor Stitt,George D. Yancopoulos,David J. Glass +15 more
TL;DR: Two genes encode ubiquitin ligases that are potential drug targets for the treatment of muscle atrophy, and mice deficient in either MAFbx orMuRF1 were found to be resistant to atrophy.
Journal ArticleDOI
Diagnoses and timing of 30-day readmissions after hospitalization for heart failure, acute myocardial infarction, or pneumonia.
Kumar Dharmarajan,Angela F. Hsieh,Zhenqiu Lin,Héctor Bueno,Joseph S. Ross,Leora I. Horwitz,José Augusto Barreto-Filho,Nancy Kim,Susannah M. Bernheim,Lisa G. Suter,Elizabeth E. Drye,Harlan M. Krumholz +11 more
TL;DR: Among Medicare fee-for-service beneficiaries hospitalized for HF, acute MI, or pneumonia, 30-day readmissions were frequent throughout the month after hospitalization and resulted from a similar spectrum of readmission diagnoses regardless of age, sex, race, or time after discharge.
Journal ArticleDOI
Analysis of Machine Learning Techniques for Heart Failure Readmissions
Bobak J. Mortazavi,Nicholas S. Downing,Emily M. Bucholz,Kumar Dharmarajan,Ajay Manhapra,Shu-Xia Li,Sahand Negahban,Harlan M. Krumholz +7 more
TL;DR: Machine learning methods improved the prediction of readmission after hospitalization for heart failure compared with LR and provided the greatest predictive range in observed readmission rates.
Journal ArticleDOI
Association Between Hospital Penalty Status Under the Hospital Readmission Reduction Program and Readmission Rates for Target and Nontarget Conditions.
Nihar R. Desai,Joseph S. Ross,Ji Young Kwon,Jeph Herrin,Kumar Dharmarajan,Susannah M. Bernheim,Harlan M. Krumholz,Leora I. Horwitz +7 more
TL;DR: Readmission rates for patients at hospitals subject to penalties under the HRRP had greater reductions in readmission rates compared with those at nonpenalized hospitals, and changes were greater for target vs nontarget conditions.
Journal ArticleDOI
Trajectories of risk after hospitalization for heart failure, acute myocardial infarction, or pneumonia: retrospective cohort study
Kumar Dharmarajan,Angela F. Hsieh,Vivek T. Kulkarni,Zhenqiu Lin,Joseph S. Ross,Leora I. Horwitz,Nancy Kim,Lisa G. Suter,Haiqun Lin,Sharon-Lise T. Normand,Harlan M. Krumholz +10 more
TL;DR: Risk declines slowly for older patients after hospitalization for heart failure, acute myocardial infarction, or pneumonia and is increased for months, but knowledge of absolute risks and their changes over time can be used to better align interventions designed to reduce adverse outcomes after discharge with the highest risk periods for patients.