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William Poueymirou
Researcher at Regeneron
Publications - 38
Citations - 7753
William Poueymirou is an academic researcher from Regeneron. The author has contributed to research in topics: Cytotoxic T cell & Antibody. The author has an hindex of 19, co-authored 34 publications receiving 6966 citations.
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Journal ArticleDOI
Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy
Sue C. Bodine,Esther Latres,Susanne Baumhueter,Venus Lai,Lorna Nunez,Brian A. Clarke,William Poueymirou,Frank J. Panaro,Erqian Na,Kumar Dharmarajan,Zhen-Qiang Pan,David M. Valenzuela,Thomas M. DeChiara,Trevor Stitt,George D. Yancopoulos,David J. Glass +15 more
TL;DR: Two genes encode ubiquitin ligases that are potential drug targets for the treatment of muscle atrophy, and mice deficient in either MAFbx orMuRF1 were found to be resistant to atrophy.
Journal ArticleDOI
The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo
Thomas M. DeChiara,David C. Bowen,David M. Valenzuela,Mary V. Simmons,William Poueymirou,Susan Thomas,Erika Kinetz,Debra L Compton,Rojas Eduardo A,John S. Park,Cynthia L. Smith,Peter S. DiStefano,David J. Glass,Steven J. Burden,George D. Yancopoulos +14 more
TL;DR: It is indicated that MuSK responds to a critical nerve-derived signal (agrin), and in turn activates signaling cascades responsible for all aspects of synapse formation, including organization of the postsynaptic membrane, synapse-specific transcription, and presynaptic differentiation.
Journal ArticleDOI
High-throughput engineering of the mouse genome coupled with high-resolution expression analysis
David M. Valenzuela,Andrew J. Murphy,David Frendewey,Nicholas W. Gale,Aris N. Economides,Wojtek Auerbach,William Poueymirou,Niels C. Adams,Rojas Jose F,Jason Yasenchak,Rostislav Chernomorsky,Marylene Boucher,Andrea L Elsasser,Lakeisha Esau,Jenny Zheng,Jennifer A. Griffiths,Xiaorong Wang,Hong Su,Yingzi Xue,Melissa G. Dominguez,Irene Noguera,Richard Torres,Macdonald Lynn,A. Francis Stewart,Thomas M. DeChiara,George D. Yancopoulos +25 more
TL;DR: The development of a high-throughput and largely automated process that uses targeting vectors based on bacterial artificial chromosomes (BACs) that permits genetic alteration with nucleotide precision, is not limited by the size of desired deletions, does not depend on isogenicity or on positive–negative selection, and can precisely replace the gene of interest with a reporter that allows for high-resolution localization of target-gene expression.
Journal ArticleDOI
Conditional Activation of Akt in Adult Skeletal Muscle Induces Rapid Hypertrophy
Ka-Man V. Lai,Michael Gonzalez,William Poueymirou,William O. Kline,Erqian Na,Elizabeth Zlotchenko,Trevor Stitt,Aris N. Economides,George D. Yancopoulos,David J. Glass +9 more
TL;DR: It is demonstrated that acute activation of Akt is sufficient to induce rapid and significant skeletal muscle hypertrophy in vivo, accompanied by activation of the downstream Akt/p70S6 kinase protein synthesis pathway.
Journal ArticleDOI
Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth
Thomas M. DeChiara,Richard Vejsada,William Poueymirou,Ann Acheson,Chitra Suri,Joanne C. Conover,Beth Friedman,Joyce McClain,Li Pan,Neil Stahl,Nancy Y. Ip,Ann Kato,George D. Yancopoulos +12 more
TL;DR: Ciliary neurotrophic factor (CNTF) supports motor neuron survival in vitro and in mouse models of motor neuron degeneration and was considered a candidate for the muscle-derived neurotrophic activity that regulates motor neurons survival during development.