K
Kunbin Qu
Publications - 13
Citations - 1116
Kunbin Qu is an academic researcher. The author has contributed to research in topics: ZAP70 & Ubiquitin ligase. The author has an hindex of 9, co-authored 11 publications receiving 1051 citations.
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Journal ArticleDOI
R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation
Sylvia Braselmann,Vanessa Taylor,Haoran Zhao,Su Wang,Catherine Sylvain,Muhammad Baluom,Kunbin Qu,Ellen Herlaar,Angela Lau,Chi Young,Brian R Wong,Scott Lovell,Thomas Sun,Gary Park,Ankush Argade,Stipo Jurcevic,Polly Pine,Rajinder Singh,Elliott B. Grossbard,Donald G. Payan,Esteban Masuda +20 more
TL;DR: A first-inhuman study is reported showing that R406 is orally bioavailable, achieving exposures capable of inhibiting Syk-dependent IgE-mediated basophil activation and showing R406 potential for modulating Syk activity in human disease.
Journal ArticleDOI
Discovering patterns to extract protein--protein interactions from full texts
TL;DR: A robust and powerful methodology to mine protein-protein interactions from biomedical texts by using a dynamic programming algorithm to compute distinguishing patterns by aligning relevant sentences and key verbs that describe protein interactions.
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The Poxvirus p28 Virulence Factor Is an E3 Ubiquitin Ligase
Jianing Huang,Qi Huang,Xiulan Zhou,Mary M. Shen,Ann Yen,Simon X. Yu,Guoqiang Dong,Kunbin Qu,Peiyong Huang,Emily Anderson,Sarkiz Daniel-Issakani,R. Mark L. Buller,Donald G. Payan,H. Henry Lu +13 more
TL;DR: It is concluded that the poxvirus p28 virulence factor is a new member of the RING finger E3 ubiquitin ligase family and has a unique polyubiquitylation activity.
Journal ArticleDOI
Drug discovery in the ubiquitin regulatory pathway.
Brian R Wong,Francesco Parlati,Kunbin Qu,Susan Demo,Todd R. Pray,Jianing Huang,Donald G. Payan,Mark K. Bennett +7 more
TL;DR: The ubiquitin enzyme cascades are reviewed, highlighting therapeutic opportunities and enzymatic mechanisms, and the challenges of targeting this class of enzymes with small molecules as well as current approaches and progress in drug discovery.
Journal ArticleDOI
Systematic identification of regulatory proteins critical for T-cell activation.
Peter C. Chu,Jorge Pardo,Haoran Zhao,Connie C. Li,Erlina Pali,Mary M. Shen,Kunbin Qu,Simon X. Yu,Betty Huang,Peiwen Yu,Esteban Masuda,Susan M. Molineaux,Frank Kolbinger,Gregorio Aversa,Jan E. de Vries,Donald G. Payan,X. Charlene Liao +16 more
TL;DR: This study identified important signal regulators in T-cell activation and demonstrated a highly efficient strategy for discovering many components of signal transduction pathways and validating them in physiological settings.