K
Kunwar Somesh Vikramdeo
Researcher at Jawaharlal Nehru University
Publications - 18
Citations - 107
Kunwar Somesh Vikramdeo is an academic researcher from Jawaharlal Nehru University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 5, co-authored 7 publications receiving 63 citations.
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Metronidazole hydrazone conjugates: Design, synthesis, antiamoebic and molecular docking studies.
Mohammad Fawad Ansari,Shadab Miyan Siddiqui,Subhash Mohan Agarwal,Kunwar Somesh Vikramdeo,Neelima Mondal,Amir Azam +5 more
TL;DR: Six compounds were found to be better inhibitors of E. histolytica than the reference drug metronidazole and showed greater than 50-60% viability against HeLa cervical cancer cell line after 72 h treatment.
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Synthesis of amino acid appended indoles: appreciable anti-fungal activity and inhibition of ergosterol biosynthesis as their probable mode of action.
Pooja,Parteek Prasher,Palwinder Singh,Kalpana Pawar,Kunwar Somesh Vikramdeo,Neelima Mondal,Sneha Sudha Komath +6 more
TL;DR: It is shown that these compounds lower ergosterol levels in the fungal cells and probably act by targeting lanosterol 14α-demethylase, a key enzyme in the sterol biosynthetic pathway of C. albicans.
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Designing novel inhibitors against histone acetyltransferase (HAT: GCN5) of Plasmodium falciparum
Amarjeet Kumar,Krishanu Bhowmick,Kunwar Somesh Vikramdeo,Neelima Mondal,Naidu Subbarao,Suman Kumar Dhar +5 more
TL;DR: 20 potential inhibitors of PfGCN5 are reported and experimental validation of one molecule with antimalarial activity at low nanomolar range is reported and Comparative molecular dynamics simulation study of one of the compounds suggested the possible reason for its selectivity.
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Design, Synthesis and Evaluation of Bifunctional Acridinine−Naphthalenediimide Redox-Active Conjugates as Antimalarials
Srikanta Dana,Sudhir Kumar Keshri,Jyoti Shukla,Kunwar Somesh Vikramdeo,Neelima Mondal,Pritam Mukhopadhyay,Suman Kumar Dhar +6 more
TL;DR: In this article, a novel class of bifunctional molecules was synthesized integrating acridine and redox-active naphthalenediimide (NDI) scaffolds directly and through a flexible linker.
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Detection of mitochondrial DNA mutations in circulating mitochondria-originated extracellular vesicles for potential diagnostic applications in pancreatic adenocarcinoma
Kunwar Somesh Vikramdeo,Shashi Anand,Mohammad Aslam Khan,Moh’d Khushman,Martin J. Heslin,Seema Singh,Ajay P. Singh,Santanu Dasgupta +7 more
TL;DR: In this article , the mtDNA mutations can be detected in circulating extracellular vesicles (EVs) of PDAC patients and used for discerning between cancer and non-cancer subjects.