S
Suman Kumar Dhar
Researcher at Jawaharlal Nehru University
Publications - 69
Citations - 2956
Suman Kumar Dhar is an academic researcher from Jawaharlal Nehru University. The author has contributed to research in topics: DNA replication & Origin recognition complex. The author has an hindex of 23, co-authored 66 publications receiving 2737 citations. Previous affiliations of Suman Kumar Dhar include Brigham and Women's Hospital.
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Journal ArticleDOI
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1.
James A. Wohlschlegel,Brian T. Dwyer,Suman Kumar Dhar,Christin Cvetic,Johannes C. Walter,Anindya Dutta +5 more
TL;DR: It is suggested that geminin inhibits inappropriate origin firing by targeting Cdt1, a recently identified replication initiation factor necessary for MCM loading in Multicellular eukaryotes.
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Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin.
Suman Kumar Dhar,Kenichi Yoshida,Yuichi J. Machida,Poonam Khaira,Biswendu Chaudhuri,James A. Wohlschlegel,Michael Leffak,John L. Yates,Anindya Dutta +8 more
TL;DR: A hypomorphic mutation made in the ORC2 gene of a human cancer cell line through homologous recombination decreased Orc2 protein levels by 90% and this defect was rescued by reintroduction of Orc2.
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Mcm10 and And-1/CTF4 recruit DNA polymerase α to chromatin for initiation of DNA replication
Wenge Zhu,Chinweike Ukomadu,Sudhakar Jha,Takeshi Senga,Suman Kumar Dhar,James A. Wohlschlegel,Leta K. Nutt,Sally Kornbluth,Anindya Dutta +8 more
TL;DR: It is shown that And-1/Ctf4 (Chromosome transmission fidelity 4) interacts with Mcm10, which associates with MCM2-7, and with the p180 subunit of DNA pol, and is therefore a new replication initiation factor that brings together the MCM 2-7 helicase and the DNA pol –primase complex.
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Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45.
James A. Wohlschlegel,Suman Kumar Dhar,Tatyana A. Prokhorova,Anindya Dutta,Johannes C. Walter +4 more
TL;DR: It is reported that Xenopus Mcm10 (XMcm10) is not required for origin binding of XMcm2-7, and the chromatin binding at the onset of DNA replication requires chromatin-bound XMc m10, and it is independent of Cdk2 and Cdc7.
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Rvb1p and Rvb2p are essential components of a chromatin remodeling complex that regulates transcription of over 5% of yeast genes.
Zophonías O. Jónsson,Suman Kumar Dhar,Geeta J. Narlikar,Roy Auty,Nikhil Wagle,David Pellman,Richard E. Pratt,Robert E. Kingston,Anindya Dutta +8 more
TL;DR: The findings show that Rvb1p and R vb2p are essential components of a chromatin remodeling complex and determine genes regulated by the complex.