K
Kurt D. Hankenson
Researcher at University of Michigan
Publications - 145
Citations - 9284
Kurt D. Hankenson is an academic researcher from University of Michigan. The author has contributed to research in topics: Osteoblast & Bone healing. The author has an hindex of 43, co-authored 134 publications receiving 7789 citations. Previous affiliations of Kurt D. Hankenson include Michigan State University & Purdue University.
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Journal ArticleDOI
GAGE: generally applicable gene set enrichment for pathway analysis
TL;DR: A new GSA method called Generally Applicable Gene-set Enrichment (GAGE) is presented, which consistently outperformed two most frequently used GSA methods and inferred statistically and biologically more relevant regulatory pathways.
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Regulation of osteoblastogenesis and bone mass by Wnt10b
Christina N. Bennett,Kenneth A. Longo,Wendy S. Wright,Larry J. Suva,Timothy F. Lane,Kurt D. Hankenson,Ormond A. MacDougald +6 more
TL;DR: In this paper, the authors used pharmacological and genetic approaches to demonstrate that canonical Wnt signaling stimulates osteoblastogenesis and inhibits adipogenesis of bipotential mesenchymal precursors.
Journal ArticleDOI
Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation.
Grace L. Lin,Kurt D. Hankenson +1 more
TL;DR: The current understanding of signaling pathways in MSC differentiation is outlined and where both spatiotemporal effects during differentiation and comparable experimental conditions need to be considered are indicated in order to clarify the outcome(s) of differing regulatory levels of these signaling pathways.
Journal ArticleDOI
Angiogenesis in bone regeneration.
TL;DR: In animal models enhancing angiogenesis promotes bone regeneration, suggesting that modifying fracture vascularization could be a viable therapeutic approach for accelerated/improved bone regeneration clinically.
Journal ArticleDOI
Wnt Signaling Stimulates Osteoblastogenesis of Mesenchymal Precursors by Suppressing CCAAT/Enhancer-binding Protein α and Peroxisome Proliferator-activated Receptor γ
Sona Kang,Christina N. Bennett,Isabelle Gerin,Lauren A. Rapp,Kurt D. Hankenson,Ormond A. MacDougald +5 more
TL;DR: It is demonstrated that transient activation of Wnt/β-catenin signaling rapidly suppresses C/EBPα and PPARγ, followed by activation of osteoblastogenic transcription factors, suggesting that Wnt signaling alters the fate of mesenchymal precursor cells primarily by suppressing C/Wntα andPPARγ.