K
Kurt Schaecher
Researcher at Medical Corps
Publications - 10
Citations - 1995
Kurt Schaecher is an academic researcher from Medical Corps. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 8, co-authored 10 publications receiving 1832 citations. Previous affiliations of Kurt Schaecher include United States Department of the Army.
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Journal ArticleDOI
Evidence of Artemisinin-Resistant Malaria in Western Cambodia
TL;DR: Artemisinins are potent and rapidly acting antimalarial drugs, and their widespread use for treating patients with Plasmodium falciparum malaria raises the question of emerging drug resistance.
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Artemisinin Resistance in Cambodia: A Clinical Trial Designed to Address an Emerging Problem in Southeast Asia
Harald Noedl,Youry Se,Sabaithip Sriwichai,Kurt Schaecher,Paktiya Teja-Isavadharm,Bryan Smith,Wiriya Rutvisuttinunt,Delia Bethell,Sittidech Surasri,Mark M. Fukuda,Duong Socheat,Lon Chan Thap +11 more
TL;DR: Artemisinin resistance has emerged along the Thai-Cambodian border and the potentially devastating implications of spreading resistance to a drug that currently has no successor call for further studies of this emerging problem.
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Artesunate Dose Escalation for the Treatment of Uncomplicated Malaria in a Region of Reported Artemisinin Resistance: A Randomized Clinical Trial
Delia Bethell,Youry Se,Chanthap Lon,Stuart D. Tyner,David Saunders,Sabaithip Sriwichai,Sea Darapiseth,Paktiya Teja-Isavadharm,Phisit Khemawoot,Kurt Schaecher,Wiriya Ruttvisutinunt,Jessica T. Lin,Worachet Kuntawungin,Panita Gosi,Ans Timmermans,Bryan Smith,Duong Socheat,Mark M. Fukuda +17 more
TL;DR: There is no pharmacodynamic benefit of increasing the daily dose of AS (4mg/kg) currently recommended for short-course combination treatment of uncomplicated malaria, even in regions with emerging artemisinin resistance, as long as the partner drug retains high efficacy.
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Polymorphism patterns in Duffy-binding protein among Thai Plasmodium vivax isolates
Panita Gosi,Panita Gosi,Srisin Khusmith,Thareerat Khalambaheti,David E. Lanar,Kurt Schaecher,Mark M. Fukuda,Scott R Miller +7 more
TL;DR: Polymorphisms within PvDBPII indicated that Thai vivax malaria parasites are genetically diverse and the difference between the rates of nonsynonymous and synonymous mutations estimated by the Nei and Gojobori's method suggested that Pv DBPII antigen appears to be under selective pressure.
Journal ArticleDOI
Plasmodium falciparum gametocyte carriage is associated with subsequent Plasmodium vivax relapse after treatment.
Jessica T. Lin,Delia Bethell,Stuart D. Tyner,Chanthap Lon,Naman K. Shah,David L. Saunders,Sabaithip Sriwichai,Phisit Khemawoot,Worachet Kuntawunggin,Bryan Smith,Harald Noedl,Kurt Schaecher,Duong Socheat,Youry Se,Steven R. Meshnick,Mark M Fukuda +15 more
TL;DR: The findings suggest that the majority of vivax infections arising after treatment of falciparum malaria originate from relapsing liver-stage parasites, which may benefit from empiric treatment with an 8-aminoquinolone such as primaquine.