Stuart D. Tyner

TL;DR: It is suggested that p53 has a role in regulating organismal ageing by generating mice with a deletion mutation in the first six exons of the p53 gene that express a truncated RNA capable of encoding a carboxy-terminal p53 fragment.

TL;DR: While there was some evidence of spreading resistance, there was no evidence of resistance moving westward from Cambodia into Myanmar, and K13 appears to be a major determinant of artemisinin resistance throughout Southeast Asia.

TL;DR: Replication and validation studies are needed to refine the location of loci responsible for artemisinin resistance and to understand the mechanism behind it; however, two SNPs on chromosomes 10 and 13 may be useful markers of delayed parasite clearance in surveillance for artesunate resistance in Southeast Asia.

TL;DR: TXA was used in approximately 10% of pediatric combat trauma patients, typically in the setting of severe abdominal or extremity trauma and metabolic acidosis and suggested significant improvements in discharge neurologic status as well as decreased ventilator dependence.

TL;DR: It is hypothesized that the reduced p53 dosage in the p53+/- cells provides an environment more conducive to the development of further oncogenic lesions and the initiation of a tumor, and to support the idea that p53 is indeed a haploinsufficient tumor suppressor, it is shown here that normal p 53+/-cells exhibit reduced parameters of growth control and stress response compared to their p53-/- counterparts.