Kyle Caution

TL;DR: It is shown for the first time that in wild-type macrophages, many B. cepacia reside in autophagosomes that fuse with lysosomes at later stages of infection, and it is demonstrated that if efficiently activated, autophagy can control B. Cepacia infection and ameliorate the associated inflammation.

TL;DR: Caspase-11 was dispensable for the fusion of lysosomes with phagosomes containing nonpathogenic bacteria, uncovering a fundamental difference in the trafficking of phagosome according to their cargo.

TL;DR: This study builds a foundation for the development of novel therapeutics aimed to improve autophagy in the elderly population and suggests a role for DNMT2 in DNA methylation activities.

TL;DR: The data demonstrate that L. pneumophila manipulates ASC levels to evade inflammasome activation and grow in human monocytes by targeting ASC, which modulates the inflammaome, the apoptosome, and NF-κB pathway simultaneously.

TL;DR: Interestingly, the depletion of p62 from ΔF508 macrophages results in the release of the autophagy molecule beclin1 (BECN1) from the mutant CFTR aggregates and allows its redistribution and recruitment to the B. cepacia vacuole, mediating the acquisition of theAutophagy marker LC3 and bacterial clearance via Autophagy.