K
Kyle Hayes
Researcher at Pfizer
Publications - 3
Citations - 63
Kyle Hayes is an academic researcher from Pfizer. The author has contributed to research in topics: RNA interference & Replicon. The author has an hindex of 2, co-authored 3 publications receiving 59 citations.
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Journal ArticleDOI
Safe, long-term hepatic expression of anti-HCV shRNA in a nonhuman primate model
David Suhy,Shih-Chu Kao,Tin Mao,Laurence O. Whiteley,Hubert Denise,B E Souberbielle,Andrew D. Burdick,Kyle Hayes,J. Fraser Wright,Helen Lavender,Peter W. Roelvink,Alexander A. Kolykhalov,Kevin Brady,Sterghios Moschos,Bernd Hauck,Olga Zelenaia,Shangzhen Zhou,Curt Scribner,Katherine A. High,Katherine A. High,Sara H Renison,Romuald Corbau +21 more
TL;DR: A novel drug is described, intended as a “single-shot ” therapy, which expresses three short hairpin RNAs (shRNAs) that simultaneously target multiple conserved regions of the HCV genome as confirmed in vitro by knockdown of an HCV replicon system.
Journal ArticleDOI
Identification and Evaluation of Novel MicroRNA Biomarkers in Plasma and Feces Associated with Drug-induced Intestinal Toxicity
Dalia Kalabat,Allison Vitsky,Wesley Scott,Erick Kindt,Kyle Hayes,Annette John-Baptiste,Wenhu Huang,Amy H. Yang +7 more
TL;DR: Preliminary evidence that select microRNAs have the potential to act as noninvasive, sensitive, and quantitative biomarkers of intestinal injury is provided.
Journal ArticleDOI
Zucker Lean Rats With Hepatic Steatosis Recapitulate Asymptomatic Metabolic Syndrome and Exhibit Greater Sensitivity to Drug-Induced Liver Injury Compared With Standard Nonclinical Sprague-Dawley Rat Model.
Timothy P. LaBranche,Anna K. Kopec,Srinivasa R. Mantena,Brett D. Hollingshead,Andrew W. Harrington,Andrew W. Harrington,Zachary S. Stewart,Yutian Zhan,Kyle Hayes,Laurence O. Whiteley,Andrew D. Burdick,John W. Davis +11 more
TL;DR: ZL rats with HFD-induced hepatic steatosis is identified as a more sensitive nonclinical in vivo test system for modeling DILI compared with SD rats fed normal chow.