B E Souberbielle

TL;DR: This review describes the three most commonly used protein transduction vehicles; the antennapedia peptide, the herpes simplex virus VP22 protein and HIV TATprotein transduction domain.

TL;DR: It is shown that human peripheral blood NK cells express the CD28 costimulatory receptor, with its detection totally dependent on the mAb used, and that B7.1 enhances the NK-mediated lysis of NK-sensitive but not ofNK-resistant tumor cells and that this increased lysis is dependent on CD28-B7 interactions as shown by the ability of Abs to block this lysis.

TL;DR: In this paper, the authors compare two types of drug-induced liver injury (DILI): intrinsic/predictable or an idiosyncratic type, and compare the two forms of DILI in their manifestation and diagnosis.

TL;DR: These doses of TLR7 stimulation results in a pharmacologic response at levels commensurate with predicted antiviral efficacy, but these doses are associated with SAEs, raising concerns about the therapeutic window of this class of compounds for the treatment of HCV infection.

TL;DR: A novel drug is described, intended as a “single-shot ” therapy, which expresses three short hairpin RNAs (shRNAs) that simultaneously target multiple conserved regions of the HCV genome as confirmed in vitro by knockdown of an HCV replicon system.