K
Kyle J. Korshavn
Researcher at University of Michigan
Publications - 23
Citations - 978
Kyle J. Korshavn is an academic researcher from University of Michigan. The author has contributed to research in topics: Protein aggregation & Lipid bilayer. The author has an hindex of 15, co-authored 23 publications receiving 801 citations. Previous affiliations of Kyle J. Korshavn include Harvard University & Valparaiso University.
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Glyoxal in aqueous ammonium sulfate solutions: products, kinetics and hydration effects.
TL;DR: The results of UV-vis absorption and NMR spectroscopy studies of solutions of glyoxal with ammonium, methylamine, and dimethylamine salts reveal that light absorbing compounds require the formation of nitrogen containing molecules.
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Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β
Kyle J. Korshavn,Cristina Satriano,Yuxi Lin,Rongchun Zhang,Mark Dulchavsky,Anirban Bhunia,Magdalena I. Ivanova,Young-Ho Lee,Carmelo La Rosa,Mi Hee Lim,Ayyalusamy Ramamoorthy +10 more
TL;DR: Mechanistic insights are provided into the roles that pathologically thin bilayers may play in Aβ aggregation on neuronal bilayers, and pathological lipid oxidation may contribute to Aβ misfolding.
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Cholesterol and metal ions in Alzheimer's disease
Hyuck Jin Lee,Kyle J. Korshavn,Akiko Kochi,Akiko Kochi,Jeffrey S. Derrick,Mi Hee Lim,Mi Hee Lim +6 more
TL;DR: The potential involvement of cholesterol and metal ions in AD neuropathogenesis in both individual and interrelated manners is discussed.
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Multi-target-directed phenol-triazole ligands as therapeutic agents for Alzheimer's disease.
Michael R. Jones,Michael R. Jones,Emilie Mathieu,Christine Dyrager,Simon Faissner,Simon Faissner,Zavier Vaillancourt,Kyle J. Korshavn,Mi Hee Lim,Ayyalusamy Ramamoorthy,V. Wee Yong,Shigeki Tsutsui,Peter K. Stys,Tim Storr +13 more
TL;DR: A series of multi-target-directed ligands are described that bind Cu, act as antioxidants, modulate Aβ peptide aggregation, and abolish Aβ toxicity in primary neurons.
Journal ArticleDOI
Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate
Diana C. Rodriguez Camargo,Diana C. Rodriguez Camargo,Diana C. Rodriguez Camargo,Kyle J. Korshavn,Alexander Jussupow,Kolio Raltchev,David Goricanec,Markus Fleisch,Riddhiman Sarkar,Kai Xue,Michaela Aichler,Gabriele Mettenleiter,Axel Walch,Carlo Camilloni,Franz Hagn,Franz Hagn,Bernd Reif,Ayyalusamy Ramamoorthy,Ayyalusamy Ramamoorthy +18 more
TL;DR: The ability of nanodiscs to trap amyloid intermediates as demonstrated could become one of the most powerful approaches to dissect the complicated misfolding pathways of protein aggregation.