K
Kylie A. Alexander
Researcher at University of Queensland
Publications - 47
Citations - 3465
Kylie A. Alexander is an academic researcher from University of Queensland. The author has contributed to research in topics: Transplantation & Bone healing. The author has an hindex of 19, co-authored 43 publications receiving 2889 citations. Previous affiliations of Kylie A. Alexander include QIMR Berghofer Medical Research Institute & Cooperative Research Centre.
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Journal ArticleDOI
Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs
Ingrid G. Winkler,Natalie A. Sims,Allison R. Pettit,Valerie Barbier,Bianca Nowlan,Falak Helwani,Ingrid J. Poulton,Nico van Rooijen,Kylie A. Alexander,Liza J. Raggatt,Jean-Pierre Levesque +10 more
TL;DR: It is established that bone marrow macrophages are pivotal to maintain the endosteal HSC niche and that the loss of such macrophage leads to the egress of HSCs into the blood.
Journal ArticleDOI
Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo.
M. K. Chang,Liza-Jane Raggatt,Kylie A. Alexander,Julia S. Kuliwaba,Nicola L. Fazzalari,Kate Schroder,Erin Maylin,Vera M. Ripoll,Vera M. Ripoll,David A. Hume,David A. Hume,Allison R. Pettit +11 more
TL;DR: It is demonstrated that OsteoMacs are an integral component of bone tissues and play a novel role in bone homeostasis through regulating osteoblast function and implicate OsteiMacs, in addition to osteoclasts and osteoblasts, as principal participants in bone dynamics.
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Osteal Macrophages Promote In Vivo Intramembranous Bone Healing in a Mouse Tibial Injury Model
Kylie A. Alexander,Ming K Chang,Erin Maylin,Thomas Kohler,Ralph Müller,Andy Wu,Nico van Rooijen,Matthew J. Sweet,David A. Hume,David A. Hume,Liza J. Raggatt,Allison R. Pettit +11 more
TL;DR: Osteomacs are established as participants in intramembranous bone healing and as targets for primary anabolic bone therapies in a mouse tibial injury model.
Journal ArticleDOI
Unraveling macrophage contributions to bone repair
TL;DR: There is strong justification to pursue strategies targeting macrophages and/or their products for improving normal bone healing and overcoming failed repair, and emerging data support that macrophage influence extends into both anabolic and catabolic phases of repair.
Journal ArticleDOI
Fracture Healing via Periosteal Callus Formation Requires Macrophages for Both Initiation and Progression of Early Endochondral Ossification
Liza J. Raggatt,Martin Wullschleger,Kylie A. Alexander,Andy Wu,Susan M. Millard,Simranpreet Kaur,Michelle Maugham,Laura S. Gregory,Roland Steck,Allison R. Pettit +9 more
TL;DR: The distribution, phenotype, and requirement of macrophages for fracture-associated inflammation and/or early anabolic progression during endochondral callus formation were investigated in this paper.