J
Jean-Pierre Levesque
Researcher at University of Queensland
Publications - 185
Citations - 9865
Jean-Pierre Levesque is an academic researcher from University of Queensland. The author has contributed to research in topics: Bone marrow & Haematopoiesis. The author has an hindex of 48, co-authored 177 publications receiving 9070 citations. Previous affiliations of Jean-Pierre Levesque include University of Illinois at Chicago & Washington University in St. Louis.
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Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide.
TL;DR: It is reported that mobilization of HPCs by GCSF coincides in vivo with the cleavage of the N-terminus of the chemokine receptor CXCR4 on H PCs resident in the BM and mobilized into the PB.
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Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs
Ingrid G. Winkler,Natalie A. Sims,Allison R. Pettit,Valerie Barbier,Bianca Nowlan,Falak Helwani,Ingrid J. Poulton,Nico van Rooijen,Kylie A. Alexander,Liza J. Raggatt,Jean-Pierre Levesque +10 more
TL;DR: It is established that bone marrow macrophages are pivotal to maintain the endosteal HSC niche and that the loss of such macrophage leads to the egress of HSCs into the blood.
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Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor
TL;DR: It is made that an essential step contributing to the mobilization of HPCs is the proteolytic cleavage of VCAM-1 expressed by BM stromal cells, an event triggered by the degranulation of neutrophils accumulating in the BM in response to the administration of G-CSF.
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G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow
Craig L. Semerad,Matthew J. Christopher,Fulu Liu,Brenton Short,Paul J. Simmons,Ingrid G. Winkler,Jean-Pierre Levesque,Jean Chappel,F. Patrick Ross,Daniel C. Link +9 more
TL;DR: Data suggest a model in which G-CSF, through an indirect mechanism, potently inhibits osteoblast activity resulting in decreased CXCL12 expression in the bone marrow, which ultimately leads to HPC mobilization.
Journal ArticleDOI
Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance
Ingrid G. Winkler,Valerie Barbier,Bianca Nowlan,Rebecca Jacobsen,Catherine E. Forristal,John T. Patton,John L. Magnani,Jean-Pierre Levesque +7 more
TL;DR: A new role for the adhesion molecule E-selectin expressed exclusively by bone marrow endothelial cells in the vascular HSC niche is reported, demonstrating that E- selectin promotes HSC proliferation and is a crucial component of the vascular niche.