Kyra L. Jordan

TL;DR: “Hit-and-run” treatment with senolytics, which in the case of D’+ Q have elimination half-lives <11 h, significantly decreases senescent cell burden in humans.

TL;DR: A single intrarenal delivery of MSC in conjunction with renal revascularization restored renal hemodynamics and function and decreased inflammation, apoptosis, oxidative stress, microvascular loss, and fibrosis.

TL;DR: EPC are renoprotective as they attenuated renal dysfunction and damage in chronic ARAS, and consequently decreased the injury signals, so manipulation of homing signals may potentially allow therapeutic opportunities to increase endogenous EPC recruitment.

TL;DR: Development of insulin resistance characterizing a transition from obesity to MetS is associated with progressive changes of myocardial autophagy, apoptosis, inflammation, mitochondrial dysfunction, and fibrosis, which may represent a novel therapeutic target for preserving myocardian structure and function in obesity and MetS.

TL;DR: Renal vein blood from post-stenotic human kidneys has multiple markers reflecting active inflammation that portends kidney injury and reduced function and may serve as novel therapeutic targets to repair the stenotic kidney.