Showing papers in "EBioMedicine in 2019"

TL;DR: The authors' first-in-humans open-label pilot supports study feasibility and provides initial evidence that senolytics may alleviate physical dysfunction in IPF, warranting evaluation of DQ in larger randomized controlled trials for senescence-related diseases.

TL;DR: “Hit-and-run” treatment with senolytics, which in the case of D’+ Q have elimination half-lives <11 h, significantly decreases senescent cell burden in humans.

TL;DR: The data suggest that specific gut microbial signatures may depict the mild cognitive impairment and that the MMKD can modulate the gut microbiome and metabolites in association with improved AD biomarkers in CSF.

TL;DR: In progression comparisons, differentially abundant taxa were inconsistent across methods and timepoints, but there was some support for a different distribution of enterotypes and a decreased abundance of Prevotella in faster-progressing patients.

TL;DR: The current - however still fragmentary - knowledge about the potential communication pathways of muscle and immune system, how they are affected by aging of skeletal muscle and possible treatment strategies are outlined and should stimulate further research in this important scientific field.

TL;DR: An immune prognostic model (IPM) based on immune-related genes that were differentially expressed between TP53WT and TP53MUT HCC samples, which resulted in the downregulation of the immune response in HCC, is established and validated.

TL;DR: Higher metastatic HCC cells can confer this potential on those with lower or no metastatic potential via exosomes with circPTGR1, resulting in increased migratory and invasive abilities in those cells.

TL;DR: The proposed clinical-immune signature is a promising biomarker for estimating overall survival in ovarian cancer and integrated with stage, grade and debulking, which showed improved prognostic accuracy than clinical characteristics only.

TL;DR: New insights are provided into the roles of gastric microbiota in different stomach microhabitats in gastric carcinogenesis, especially the pathogenesis of HP.

TL;DR: The involvement of the circPTPRA/miR-96-5p/RASSF8/E-cadherin axis dysregulation in NSCLC tumor progression can be leveraged as a potential treatment avenue inNSCLC.

TL;DR: Wang et al. as discussed by the authors explored whether the PLK1 inhibitor BI2536 is able to sensitize ESCC cells to cisplatin (DDP) and determine the underlying mechanisms.

TL;DR: Three major subtypes of HCC were identified by performing integrative analysis of two omics data sets, and it was clarified that this classification was closely correlated with clinicopathological factors, immune profiles and recurrence patterns.

TL;DR: The results demonstrate an oncogenic role of m6A-modified ITGA6 and show its regulatory mechanisms in BC development and progression, thus identifying a potential therapeutic target for BC.

TL;DR: Existing non-vaccine-serotypes in most GPSCs preclude the removal of these lineages by pneumococcal conjugate vaccines; leaving potential for serotype replacement, and a subset of GPSCs have increased resistance, and/or serotype-independent invasiveness.

TL;DR: It is shown that by restoring miR-494-3p levels through expression of an engineered miRNA mimic the authors can downregulate Sema3A levels in MNs and increases MN survival in vitro, supporting the pathological importance of this pathway inMNs and its therapeutic potential.

TL;DR: These results suggest that circulating miR-1238 serves as a clinical biomarker and a promising therapeutic target for TMZ resistance in GBM and that exosomal miR/CAV1 may confer chemoresistance in the tumour microenvironment.

TL;DR: It is reported that RBM3 is crucial for the SCD-circRNA 2 formation in HCC cells, which not only provides mechanistic insights into cancer-related circRNA dysregulation but also establishes R BM3 as an oncogene with both therapeutic potential and prognostic value.

TL;DR: By blocking accelerated senescence following therapy, senolytics might prevent and potentially even revert premature frailty in cancer survivors, and this becomes pertinent because treatments that are senostatic in vitro persistently reduce numbers of senescent cells in vivo, i.e. act as net senolytic in immunocompetent hosts.

TL;DR: GLS1 (both KGA and GAC isoform) is highly expressed in HCC, and that high expression of GAC predicts a poor prognosis, which implied that GLS1 could serve as a therapeutic target for elimination of CSCs.

TL;DR: It is anticipated that KRAS mutant NSCLC will be the most important molecular subset of cancer to evaluate the combination of small molecules and immune checkpoint inhibitors (CPI).

TL;DR: A multi-scale RNN model is proposed, which enables classification between 558 schizophrenia and 542 healthy controls by using time courses of fMRI independent components (ICs) directly and shows the potential for multi- scale RNN-based neuroimaging classifications.

TL;DR: Cervicovaginal metabolic profiles were driven by cancer followed by genital inflammation, HPV infection, and vaginal microbiota, providing evidence for metabolite-driven complex host-microbe interactions as hallmarks of cervical cancer with future translational potential.

TL;DR: Wang et al. as mentioned in this paper found that miR-873 inhibited PD-L1 expression through directly binding to its 3′-untranslated region (UTR), and miR873 attenuated the stemness and chemoresistance of breast cancer cells which was dependent on the downstream PI3K/Akt and ERK1/2 signaling.

TL;DR: A three-feature radiomics signature that demonstrated favorable prediction of HCC recurrence across all datasets and promises to accurately predict individual recurrence risk that may facilitate personalized HCC management is identified.

TL;DR: The microbiome analysis combined with serum metabolomics can shed new light onto the pathogenesis of fibromyalgia and propose several molecules as potential biomarkers that can be used to evaluate the current diagnostic criteria.

TL;DR: The data indicate that the level of tumor ablation correlates with increased activation of cellular immunity, and shows that the decrease in metastatic lesions is dependent on the intact immune system and H-FIRE generates 4T1 neoantigens that engage the adaptive immune system to significantly attenuate tumor progression.

TL;DR: Downregulation of circDNMT3B contributes to vascular dysfunction in diabetic retinas through regulating miR-20b-5p and BAMBI, providing a potential treatment strategy for diabetic retinopathy.

TL;DR: The TREM1 predictive signal was anti-TNF specific, as no changes were seen in ustekinumab and vedolizumab treated patients, and can aid in the selection of therapy in biologic-naïve patients.

TL;DR: This review summarizes recent findings regarding the associations between islet autoimmunity, T1D, and the intestinal microbiota.

TL;DR: Results reveal PICSAR may exert an essential role in promoting synovial invasion and joint destruction by sponging miR-4701-5p in RA and that lncRNA PICS AR may act as a biomarker of RA.