K
Kyung H. Gahm
Researcher at Amgen
Publications - 24
Citations - 852
Kyung H. Gahm is an academic researcher from Amgen. The author has contributed to research in topics: Supercritical fluid chromatography & Enantiomer. The author has an hindex of 13, co-authored 24 publications receiving 824 citations. Previous affiliations of Kyung H. Gahm include Pharmacia & University of Cincinnati.
Papers
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Journal ArticleDOI
Application of Sulfated Cyclodextrins to Chiral Separations by Capillary Zone Electrophoresis
Apryll M. Stalcup,Kyung H. Gahm +1 more
TL;DR: Mixtures of randomly substituted sulfated cyclodextrins were successfully used as chiral additives for the enantioseparation of 56 compounds of pharmaceutical interest, including anesthetics, antiarrhythmics, antidepressants, anticonvulsants, antihistamines, antihypertensives, antimalarials, relaxants, and bronchodilators.
Journal ArticleDOI
Evaluation of the macrocyclic antibiotic avoparcin as a new chiral selector for HPLC.
K. Helen Ekborg-Ott,John P. Kullman,Xiande Wang,Kyung H. Gahm,Lingfeng He,Daniel W. Armstrong,Daniel W. Armstrong +6 more
TL;DR: The use of this CSP and the optimization of separations on it are discussed, and avoparcin appears to be a useful addition to this family of CSPs.
Journal ArticleDOI
Discovery of a Potent, Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor for Clinical Study: Identification of (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221)
Murielle M. Véniant,Clarence Hale,Randall W. Hungate,Kyung H. Gahm,Maurice Emery,Janan Jona,Smriti Joseph,Jeffrey Adams,Andrew Hague,George A. Moniz,Jiandong Zhang,Michael D. Bartberger,Vivian S. W. Li,Rashid Syed,Steven R. Jordan,Renee Komorowski,Michelle Chen,Rod Cupples,Ki Won Kim,David J. St. Jean,Lars Johansson,Martin Henriksson,Meredith Williams,Jerk Vallgarda,Christopher H. Fotsch,Minghan Wang +25 more
TL;DR: Thiazolones with an exo-norbornylamine at the 2-position and an isopropyl group on the 5-position are potent 11beta-HSD1 inhibitors, but the C-5 center was prone to epimerization in vitro and in vivo, forming a less potent diastereomer.
Journal ArticleDOI
Enantioselective separation of racemic secondary amines on a chiral crown ether-based liquid chromatography stationary phase
TL;DR: The first general enantioselective separation of racemic secondary amines on a crown ether-based liquid chromatography chiral stationary phase (CSP) is presented.
Journal ArticleDOI
Quinine as a chiral additive in nonaqueous capillary zone electrophoresis
Apryll M. Stalcup,Kyung H. Gahm +1 more
TL;DR: Quinine was used as a chiral additive in nonaqueous capillary zone electrophoresis as mentioned in this paper, where the separation buffer consisted of ammonium acetate and quinine in methanol.