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Kyung Mi Lee

Researcher at Korea University

Publications -  112
Citations -  6470

Kyung Mi Lee is an academic researcher from Korea University. The author has contributed to research in topics: Cytotoxic T cell & Interleukin 21. The author has an hindex of 40, co-authored 106 publications receiving 5540 citations.

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Elevated TGF-β1 Secretion and Down-Modulation of NKG2D Underlies Impaired NK Cytotoxicity in Cancer Patients

TL;DR: Evidence is shown that TGF-β1 secreted by tumors is responsible for the poor NK lytic activity via down-regulating an NK-activating receptor, NKG2D, via secretion of TGF -β1.
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SIRT1 promotes DNA repair activity and deacetylation of Ku70.

TL;DR: The present study shows that, upon exposure to radiation, SIRT1 could enhance DNA repair capacity and deacetylation of repair protein Ku70 and physically complexed with repairprotein Ku70, leading to subsequent de acetylation.

Activation of MAP Kinases by Calcium-dependent and Calcium- independent Pathways

TL;DR: In this article, the effect of calcium mobilization on mitogen-activated protein (MAP) kinase activation was investigated using single cell image analysis using fura-2 and correlated with MAP kinase stimulation as assessed by immunoprecipitation, kinase renaturation assays and immunoblotting.
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Activation of MAP kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factor.

TL;DR: There are at least two independent pathways for stimulation of MAP kinase: one that is dependent on intracellular calcium mobilization, and one that was mediated by the tyrosine kinase epidermal growth factor receptor and is calcium-independent.