Kyung Seuk Song

TL;DR: The target organ for the silver nanoparticles was found to be the liver in both the male and female rats, and a NOAEL of 30 mg/kg and the lowest observable adverse effect level of 125mg/kg are suggested from the present study.

TL;DR: The results showed that the size of the silver nanoparticles did not affect their tissue distribution, and biological barriers, such as the blood–brain barrier and blood-testis barrier, seemed to play an important role in the silver clearance from these tissues.

TL;DR: Tissue distribution of gold nanoparticles showed a dose-dependent accumulation of gold in only lungs and kidneys with a gender-related difference in gold nanoparticle content in kidneys, and changes observed in lung histopathology and function in high-dose animals indicate that the highest concentration (20 μg/m3) is a LOAEL and the middle concentration is a NOAEL for this study.

TL;DR: Exposure to silver nanoparticles by inhalation for 90 days does not induce genetic toxicity in male and female rat bone marrow in vivo, and there were no statistically significant differences in the micronucleated polychromatic erythrocytes or in the ratio of polychromatics among the total ery Throcytes after silver nanoparticle exposure when compared with the control.

TL;DR: The data suggest that the anticancer effects of baicalein are mainly due to autophagic cell death through activation of the AMPK/ULK1 pathway and inhibition of mTOR/Raptor complex 1 expression.