K
Kyung Young Kim
Researcher at National Institutes of Health
Publications - 13
Citations - 1693
Kyung Young Kim is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 11, co-authored 13 publications receiving 1684 citations.
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Journal ArticleDOI
Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.
Seong-Jin Kim,Peter Angel,Robert Lafyatis,Kazue Hattori,Kyung Young Kim,Michael B. Sporn,Michael Karin,Anita B. Roberts +7 more
TL;DR: These results demonstrate that both components of the AP-1 complex are required for TGF-beta 1 autoinduction, and may amplify the action of TGF -beta 1 during normal development and oncogenesis.
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Transactivation of the transforming growth factor beta 1 (TGF-beta 1) gene by human T lymphotropic virus type 1 tax: a potential mechanism for the increased production of TGF-beta 1 in adult T cell leukemia.
Seong-Jin Kim,John H. Kehrl,Jack D. Burton,Craig L. Tendler,Kuan-Teh Jeang,David Danielpour,C. Thevenin,Kyung Young Kim,Michael B. Sporn,Anita B. Roberts +9 more
TL;DR: A role for Tax in the upregulation of TGF-beta 1 in HTLV-I-infected cells is suggested, which is similar to that suggested for T lymphotropic virus type 1.
Journal ArticleDOI
Activation of the second promoter of the transforming growth factor-beta 1 gene by transforming growth factor-beta 1 and phorbol ester occurs through the same target sequences.
Seong-Jin Kim,Fabienne Denhez,Kyung Young Kim,Jeffrey T. Holt,Jeffrey T. Holt,Michael B. Sporn,Anita B. Roberts +6 more
TL;DR: DNase I footprinting and gel mobility shift assays showed that binding to an Sp1 site and the putative TRE elements are required for maximal expression of the second promoter region of the TGF-beta 1 gene, suggesting that AP-1, which is capable of conferring phorbol ester or TGF
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Post-transcriptional regulation of the human transforming growth factor-beta 1 gene.
Sungmee Kim,K. Park,David M. Koeller,Kyung Young Kim,Lalage M. Wakefield,Michael B. Sporn,Anita B. Roberts +6 more
TL;DR: Computer analysis showed that this region of the 5'-UTR contained a stable secondary stem-loop structure alone is sufficient to inhibit expression of the growth hormone gene, suggesting that it plays an important role in post-transcriptional regulation of TGF-beta 1 gene expression.
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Sandwich Enzyme-Linked Immunosorbent Assays (Selisas) Quantitate and Distinguish Two Forms of Transforming Growth Factor-Beta (TGF-β1 and TGF-β2) in Complex Biological Fluids
David Danielpour,Kyung Young Kim,Linda L. Dart,Shinichi Watanabe,Anita B. Roberts,Michael B. Sporn +5 more
TL;DR: The SELISAs reported here represent the most specific, rapid, and precise assays for TGF-beta 1 and TGF -beta 2 reported thus far.