Showing papers by "Kyusik Yun published in 2017"
TL;DR: Stable, nontoxic and red fluorescent emission BSA-Au NCs for selective detection of L-dopamine (DA) in cerebrospinal fluid (CSF) and as-prepared BSA -AuNCs will gain possible strategy and good platform for biosensor, drug discovery, and rapid disease diagnosis such as Parkinson’s and Alzheimer diseases.
Abstract: Since the last two decades, protein conjugated fluorescent gold nanoclusters (NCs) owe much attention in the field of medical and nanobiotechnology due to their excellent photo stability characteristics. In this paper, we reported stable, nontoxic and red fluorescent emission BSA-Au NCs for selective detection of L-dopamine (DA) in cerebrospinal fluid (CSF). The evolution was probed by various instrumental techniques such as UV-vis spectroscopy, High resolution transmission electron microscopy (HTEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), photoluminescence spectroscopy (PL). The synthesised BSA-Au NCs were showing 4–6 nm with high fluorescent ~8% Quantum yield (QY). The fluorescence intensity of BSA-Au NCs was quenched upon the addition of various concentrations of DA via an electron transfer mechanism. The decrease in BSA-Au NCs fluorescence intensity made it possible to determine DA in PBS buffer and the spiked DA in CSF in the linear range from 0 to 10 nM with the limit of detection (LOD) 0.622 and 0.830 nM respectively. Best of our knowledge, as-prepared BSA-Au NCs will gain possible strategy and good platform for biosensor, drug discovery, and rapid disease diagnosis such as Parkinson’s and Alzheimer diseases.
175 citations
TL;DR: In this paper, a composite of AgNWs-Polyaniline (PANI) and glassy carbon electrode (GCE) was fabricated for the sensitive electrochemical determination of 4-nitrophenol (4-NP).
Abstract: Silver Nanowire-Polyaniline (AgNWs-PANI) composite modified glassy carbon electrode (GCE) was fabricated for the sensitive electrochemical determination of 4-nitrophenol (4-NP). AgNWs-PANI composite was synthesized in two steps process. The synthesized AgNWs-PANI was characterized by UV–vis, FTIR, SEM and TEM analysis. The electrochemical reduction determination of 4-NP under optimized conditions exhibited a reduction peak at −0.77 V with higher current response compared with bare GCE and AgNWs modified glassy carbon electrode (AgNWs/GCE). Effect of pH and scan rate was investigated to examine the proton transfer number, electron transfer number, electron transfer coefficient and standard rate constant of electrode. Under optimized condition, the reduction peak current and the concentration of 4-NP exhibits the linear relation with the concentration range from 0.6–32 μM, and the limit of detection was determined to be 52 nM (S/N = 3). Although, AgNWs-PANI/GCE were applied to detect the determination the 4-NP in real water samples at the recover ranging from 97.0–101.5%.
125 citations
TL;DR: It is demonstrated that GQDs have potential in biomedical applications, even though their functionalities may be different, and the cytotoxicity in NHDF and HeLa cell line was evaluated.
4 citations