L
L. David Sibley
Researcher at Washington University in St. Louis
Publications - 255
Citations - 24685
L. David Sibley is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Toxoplasma gondii & Intracellular parasite. The author has an hindex of 89, co-authored 241 publications receiving 22049 citations. Previous affiliations of L. David Sibley include University of Washington & Stanford University.
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Virulent strains of Toxoplasma gondii comprise a single clonal lineage
TL;DR: Analysis of 28 strains from a variety of hosts on five continents suggests that virulent strains of T. gondii originated from a single lineage which has remained genetically homogeneous despite being globally widespread, and despite the ability of this organism to reproduce sexually.
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Toxoplasma Invasion of Mammalian Cells Is Powered by the Actin Cytoskeleton of the Parasite
TL;DR: It is concluded that host cell invasion by Toxoplasma, and likely by related Apicomplexans, is actively powered by an actin-based contractile system in the parasite.
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Cytoskeleton of Apicomplexan Parasites
TL;DR: The unusual properties of actin and myosin in the Apicomplexa, the highly stereotyped microtubule populations in apicOMplexans, and a network of recently discovered novel intermediate filament-like elements in these parasites are discussed.
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Modulation of innate immunity by Toxoplasma gondii virulence effectors
TL;DR: Recent advances that illustrate how virulence factors disarm innate immunity and promote survival of the parasite are reviewed.
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Efficient Gene Disruption in Diverse Strains of Toxoplasma gondii Using CRISPR/CAS9
TL;DR: A new genetic system based on CRISPR/CAS9 is imported, which allows high efficiency of targeted gene disruption in natural isolates of T. gondii, allowing exploration of a much wider spectrum of biological diversity.