L
L.S. Nielsen
Researcher at University of Copenhagen
Publications - 20
Citations - 4207
L.S. Nielsen is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Plasminogen activator & Urokinase. The author has an hindex of 16, co-authored 20 publications receiving 4189 citations. Previous affiliations of L.S. Nielsen include Finsen Laboratory.
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Book ChapterDOI
Plasminogen activators, tissue degradation, and cancer.
Keld Danø,Peter A. Andreasen,J Grøndahl-Hansen,Peter Marcus Kristensen,L.S. Nielsen,L. Skriver +5 more
TL;DR: This chapter describes two types of plasminogen activators—namely, the urokinase-type plasMinogen activator (u-PA) and the tissue- type plasmineg activator(t-PA), which are essentially different gene products.
Journal ArticleDOI
Distinct localizations of urokinase-type plasminogen activator and its type 1 inhibitor under cultured human fibroblasts and sarcoma cells
Jari Pöllänen,Olli Saksela,E M Salonen,Peter A. Andreasen,L.S. Nielsen,Keld Dano,Antti Vaheri +6 more
TL;DR: The confinement of u-PA to discrete contact sites and the more uniform distribution of PAI-1 on the cell substratum may explain how cells producing large amounts of enzyme inhibitors can produce PA-mediated focal proteolysis.
Journal ArticleDOI
Transforming growth factor-beta is a strong and fast acting positive regulator of the level of type-1 plasminogen activator inhibitor mRNA in WI-38 human lung fibroblasts.
Leif R. Lund,Andrea Riccio,Peter A. Andreasen,L.S. Nielsen,Peter Kristensen,M. Laiho,O. Saksela,Francesco Blasi,Keld Dano +8 more
TL;DR: The results suggest a primary effect of TGF‐beta on PAI‐1 gene transcription, and also suggest the possibility that the transcription of this gene in non‐induced cells may be suppressed by a short‐lived negatively regulating protein.
Journal ArticleDOI
Immunocytochemical localization of urokinase-type plasminogen activator in Lewis lung carcinoma.
TL;DR: The invasively growing and metasizing Lewis lung carcinoma consistently contained urokinase-type plasminogen activator (u-PA) enzyme activity and immunoreactivity occurred both with a perinuclear cytoplasmic localization in tumor cells and associated with apparently extracellular material.
Journal ArticleDOI
Distribution of urokinase-type plasminogen activator immunoreactivity in the mouse.
TL;DR: Immunocytochemistry, using rabbit antibodies to a urokinase-type 48- Kdalton Mr mouse plasminogen activator, showed that enzyme immunoreactivity is widely distributed in the normal mouse.